RNA-based therapeutics: an overview and prospectus.
Cell Death Dis
; 13(7): 644, 2022 Jul 23.
Article
in English
| MEDLINE | ID: covidwho-1955799
ABSTRACT
The growing understanding of RNA functions and their crucial roles in diseases promotes the application of various RNAs to selectively function on hitherto "undruggable" proteins, transcripts and genes, thus potentially broadening the therapeutic targets. Several RNA-based medications have been approved for clinical use, while others are still under investigation or preclinical trials. Various techniques have been explored to promote RNA intracellular trafficking and metabolic stability, despite significant challenges in developing RNA-based therapeutics. In this review, the mechanisms of action, challenges, solutions, and clinical application of RNA-based therapeutics have been comprehensively summarized.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
RNA, Small Interfering
Type of study:
Prognostic study
Language:
English
Journal:
Cell Death Dis
Year:
2022
Document Type:
Article
Affiliation country:
S41419-022-05075-2
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