Symptomatic but not Asymptomatic COVID-19 Impairs Conditioned Pain Modulation in Young Adults.
J Pain
; 23(11): 1923-1932, 2022 Nov.
Article
in English
| MEDLINE | ID: covidwho-1956236
ABSTRACT
Pain is a common symptom reported in COVID-19 patients. Impaired endogenous pain-modulatory mechanisms such as conditioned pain modulation (CPM), and exercise-induced hypoalgesia (EIH) have been found in chronic pain conditions but is often overlooked in acute conditions that evoke painful symptoms, such as COVID-19. The purpose was to compare pressure-pain sensitivity, CPM, and EIH function among individuals who previously had COVID-19, both symptomatically and asymptomatically, and a healthy control group. Pressure pain thresholds of 59 participants were assessed in the forearm and leg using a pressure algometer before and after 1) submersion of their dominant foot in cold water (2°C) for 1min; and 2) isometric knee extension performed to task-failure at 25% of their maximal contraction. The CPM response was attenuated in individuals who were infected with symptomatic COVID-19 (N = 26) compared to asymptomatic COVID-19 (N = 13) in arm (-1.0% ± 20.3 vs 33.3% ± 26.2; P < .001) and leg (12.8% ± 22.0 vs 33.8% ± 28.2; P = .014) and compared to controls (N = 20) in arm only (-1.0% ± 26.2 vs 23.4% ± 28.2; P = .004). The EIH response was not different between groups. CPM was impaired in individuals who had symptomatic COVID-19, which may have long-term implications on pain modulation. PERSPECTIVE This study reveals that CPM was impaired in individuals who had symptomatic COVID-19 during the first wave of COVID-19, pre vaccine. These findings present a preliminary motive to study the long-term implications of COVID-19 and its effects on pain modulation.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Chronic Pain
/
COVID-19
Type of study:
Experimental Studies
/
Randomized controlled trials
Topics:
Long Covid
/
Vaccines
Limits:
Adult
/
Humans
/
Young adult
Language:
English
Journal:
J Pain
Journal subject:
Neurology
/
Psychophysiology
Year:
2022
Document Type:
Article
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