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Targeting the tissue-complosome for curbing inflammatory disease.
Dutta, Kuheli; Friscic, Jasna; Hoffmann, Markus H.
  • Dutta K; Department of Dermatology, Allergology, and Venereology, University of Lübeck, Lübeck, Germany.
  • Friscic J; Department of Dermatology, Allergology, and Venereology, University of Lübeck, Lübeck, Germany.
  • Hoffmann MH; Department of Dermatology, Allergology, and Venereology, University of Lübeck, Lübeck, Germany. Electronic address: markus.hoffmann@uni-luebeck.de.
Semin Immunol ; : 101644, 2022 Jul 25.
Article in English | MEDLINE | ID: covidwho-1956344
ABSTRACT
Hyperactivated local tissue is a cardinal feature of immune-mediated inflammatory diseases of various organs such as the joints, the gut, the skin, or the lungs. Tissue-resident structural and stromal cells, which get primed during repeated or long-lasting bouts of inflammation form the basis of this sensitization of the tissue. During priming, cells change their metabolism to make them fit for the heightened energy demands that occur during persistent inflammation. Epigenetic changes and, curiously, an activation of intracellularly expressed parts of the complement system drive this metabolic invigoration and enable tissue-resident cells and infiltrating immune cells to employ an arsenal of inflammatory functions, including activation of inflammasomes. Here we provide a current overview on complement activation and inflammatory transformation in tissue-occupying cells, focusing on fibroblasts during arthritis, and illustrate ways how therapeutics directed at complement C3 could potentially target the complosome to unprime cells in the tissue and induce long-lasting abatement of inflammation.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Semin Immunol Journal subject: Allergy and Immunology Year: 2022 Document Type: Article Affiliation country: J.smim.2022.101644

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Semin Immunol Journal subject: Allergy and Immunology Year: 2022 Document Type: Article Affiliation country: J.smim.2022.101644