Your browser doesn't support javascript.
Bullous pemphigoid triggered by COVID-19 vaccination: two cases treated with immunosuppression
British Journal of Dermatology ; 186(6):e249, 2022.
Article in English | EMBASE | ID: covidwho-1956691
ABSTRACT
Bullous pemphigoid (BP) triggered by vaccination is a rare but recognized phenomenon. We report two cases of BP triggered by covid-19 vaccinations. A 64-year-old woman was referred with a recurrent blistering rash, erupting within 7 days of both her first and second doses of the Pfizer COVID-19 vaccine. She presented with widespread annular erosions and some targetoid lesions on an urticated background across her torso and limbs. Full blood count reported significant eosinophilia. Skin biopsies were consistent with BP, demonstrating linear deposition of IgG and C3 at the dermoepidermal junction. Treatment with prednisolone 60 mg once daily and topical clobetasol propionate was commenced. Her condition progressed leading to the addition of mycophenolate mofetil 500 mg twice daily, later increased to 1 g twice daily. This was effective;autoimmune bullous skin disorder intensity scores improved from 44 to 16.5 within 1 month. An 82-year-old man presented with a 5-month history of a widespread blistering rash, with onset 2 weeks following his second dose of the AstraZeneca COVID-19 vaccine. Skin histopathology confirmed BP. He was treated with topical clobetasol propionate, a 30-day course of doxycycline and prednisolone 40 mg once daily, which is being reduced in correlation with clinical response. There have been 13 reported cases of BP triggered by COVID-19 vaccinations;these two cases highlight more are likely to occur. We need to be prepared to manage these patients with long-term immunosuppressive therapies and support them in making a shared decision to complete their vaccination programme, including booster doses during the ongoing pandemic.
Keywords

Full text: Available Collection: Databases of international organizations Database: EMBASE Topics: Vaccines Language: English Journal: British Journal of Dermatology Year: 2022 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: Databases of international organizations Database: EMBASE Topics: Vaccines Language: English Journal: British Journal of Dermatology Year: 2022 Document Type: Article