LESIONS MIMICKING KAPOSI SARCOMA IN A WOMAN LIVING WITH HIV FOLLOWING PFIZER-BIONTECH COVID- 19 VACCINATION
Sexually Transmitted Infections
; 98:A35-A36, 2022.
Article
in English
| EMBASE | ID: covidwho-1956910
ABSTRACT
Introduction A spectrum of skin reactions following mRNA COVID vaccinations have been reported that can mimic dermatological manifestations of Human Immunodeficiency Virus (HIV) infection. Case Description A 47-year-old Zimbabwean female living with HIV since 2011 (nadir CD4 366 cells/mm3) was seen in our HIV clinic with a widespread rash and raised, itchy lesions over her body measuring approximately 5-7mm which appeared three weeks after her first Pfizer-BioNTech COVID-19 vaccine. There was no systemic involvement. Her CD4 count was 641 cells/mm3 (44%) with a fully suppressed viral load on antiretroviral therapy since June 2015 with no other pertinent medical history. There was no response to topical anti-fungal therapy but symptomatic relief with anti-pruritic and anti-histamine was noted. Treatment with oral erythromycin 500mg four times a day for two weeks decreased the size of the lesions and improved the rash. A punch biopsy of pale brown skin at this time was performed with appearances in keeping with those of a lichenoid pattern of inflammation. Our patient continues to improve with erythromycin.Topical or systemic corticosteroid therapy can be considered to further ameliorate her condition. Discussion Lichenoid drug eruptions are well recognized. Our case demonstrates such a reaction to the Pfizer-BioNTech COVID-19 vaccination which adds to cases described in the contemporary medical literature. It is vital to recognize this complication in our specialty as lesions may mimic lichen planus clinically and histologically and may be mistaken for dermatological manifestations associated with HIV, including Kaposi Sarcoma (KS) and bacillary angiomatosis, which can manifest regardless of immune status.
antifungal agent; antihistaminic agent; antipruritic agent; CD4 antigen; endogenous compound; erythromycin; tozinameran; adult; antiretroviral therapy; bacillary angiomatosis; case report; CD4 lymphocyte count; clinical article; complication; conference abstract; coronavirus disease 2019; corticosteroid therapy; drug eruption; drug therapy; female; histopathology; human; Human immunodeficiency virus infected patient; immune status; inflammation; Kaposi sarcoma; lichen planus; lichenoid; medical history; medical literature; middle aged; punch biopsy; rash; skin manifestation; topical drug administration; vaccination; virus load; Zimbabwean
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Topics:
Vaccines
Language:
English
Journal:
Sexually Transmitted Infections
Year:
2022
Document Type:
Article
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