Persistent blood DNA methylation changes one year after SARS-CoV-2 infection.
Clin Epigenetics
; 14(1): 94, 2022 07 23.
Article
in English
| MEDLINE | ID: covidwho-1957069
ABSTRACT
We recently reported the COVID-19-induced circulating leukocytes DNA methylation profile. Here, we hypothesized that some of these genes would persist differentially methylated after disease resolution. Fifteen participants previously hospitalized for SARS-CoV-2 infection were epityped one year after discharge. Of the 1505 acute illness-induced differentially methylated regions (DMRs) previously identified, we found 71 regions with persisted differentially methylated, with an average of 7 serial CpG positions per DMR. Sixty-four DMRs persisted hypermethylated, and 7 DMR persisted hypomethylated. These data are the first reported evidence that DNA methylation changes in circulating leukocytes endure long after recovery from acute illness.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
DNA Methylation
/
COVID-19
Limits:
Humans
Language:
English
Journal:
Clin Epigenetics
Year:
2022
Document Type:
Article
Affiliation country:
S13148-022-01313-8
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