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Prognostic Role of sST2 in Acute Heart Failure and COVID-19 Infection-A Narrative Review on Pathophysiology and Clinical Prospective.
Marino, Luca; Concistrè, Antonio; Suppa, Marianna; Galardo, Gioacchino; Rosa, Antonello; Bertazzoni, Giuliano; Pugliese, Francesco; Letizia, Claudio; Petramala, Luigi.
  • Marino L; Department of Mechanical and Aerospace Engineering, "Sapienza" University of Rome, 00161 Rome, Italy.
  • Concistrè A; Emergency Medicine Unit, Department of Emergency-Acceptance, Critical Areas and Trauma, Policlinico "Umberto I", 00161 Rome, Italy.
  • Suppa M; Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, Italy.
  • Galardo G; Emergency Medicine Unit, Department of Emergency-Acceptance, Critical Areas and Trauma, Policlinico "Umberto I", 00161 Rome, Italy.
  • Rosa A; Emergency Medicine Unit, Department of Emergency-Acceptance, Critical Areas and Trauma, Policlinico "Umberto I", 00161 Rome, Italy.
  • Bertazzoni G; Emergency Medicine Unit, Department of Emergency-Acceptance, Critical Areas and Trauma, Policlinico "Umberto I", 00161 Rome, Italy.
  • Pugliese F; Emergency Medicine Unit, Department of Emergency-Acceptance, Critical Areas and Trauma, Policlinico "Umberto I", 00161 Rome, Italy.
  • Letizia C; Department of General Surgery and Surgical Specialties "Paride Stefanini", "Sapienza" University of Rome, 00161 Rome, Italy.
  • Petramala L; Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Int J Mol Sci ; 23(15)2022 Jul 26.
Article in English | MEDLINE | ID: covidwho-1957351
ABSTRACT
The importance of cardiovascular biomarkers in clinical practice increased dramatically in the last years, and the interest extends from the diagnosis purpose to prognostic applications and response to specific treatment. Acute heart failure, ischemic heart failure, and COVID-19 infection represent different clinical settings that are challenging in terms of the proper prognostic establishment. The aim of the present review is to establish the useful role of sST2, the soluble form of the interleukin-1 receptor superfamily (ST2), physiologically involved in the signaling of interleukin-33 (IL-33)-ST2 axis, in the clinical setting of acute heart failure (HF), ischemic heart disease, and SARS-CoV-2 acute infection. Molecular mechanisms associated with the IL33/ST2 signaling pathways are discussed in view of the clinical usefulness of biomarkers to early diagnosis, evaluation therapy to response, and prediction of adverse outcomes in cardiovascular diseases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Heart Failure Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Reviews Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ijms23158230

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Heart Failure Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Reviews Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ijms23158230