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Surveillance of influenza B severe hospitalized cases during 10 seasons in Catalonia: Does the lineage make a difference?
Soldevila, Núria; Basile, Luca; Martínez, Ana; Torner, Núria; Marcos, M Ángeles; Mosquera, Maria Del Mar; Antón, Andrés; Andrés, Cristina; Rius, Cristina; Pumarola, Tomàs; Domínguez, Ángela.
  • Soldevila N; Department of Medicine, University of Barcelona, Barcelona, Spain.
  • Basile L; Public Health Agency of Catalonia, Barcelona, Spain.
  • Martínez A; Public Health Agency of Catalonia, Barcelona, Spain.
  • Torner N; Ciber Epidemiology and Public Health CIBERESP, Instituto de Salud Carlos III, Madrid, Spain.
  • Marcos MÁ; Department of Medicine, University of Barcelona, Barcelona, Spain.
  • Mosquera MDM; Ciber Epidemiology and Public Health CIBERESP, Instituto de Salud Carlos III, Madrid, Spain.
  • Antón A; Department of Microbiology, Hospital Clínic of Barcelona, Barcelona, Spain.
  • Andrés C; Department of Microbiology, Hospital Clínic of Barcelona, Barcelona, Spain.
  • Rius C; Respiratory Viruses Unit, Microbiology Department, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Pumarola T; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.
  • Domínguez Á; Respiratory Viruses Unit, Microbiology Department, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona, Barcelona, Spain.
J Med Virol ; 94(9): 4417-4424, 2022 09.
Article in English | MEDLINE | ID: covidwho-1958806
ABSTRACT
Influenza B viruses circulate in two lineages (B/Victoria and B/Yamagata). Although classically affecting children, recently it has shown a high rate of infection and increased hospitalization in the elderly. To describe and analyze the clinical and epidemiological characteristics of severe hospitalized laboratory-confirmed influenza B virus (SHLCI-B) cases in Catalonia associated with mismatch from Influenza B virus strain included in the trivalent influenza vaccine (TIV). SHLCI-B was registered by the influenza sentinel surveillance system of Catalonia (PIDIRAC) during ten surveillance seasons from 2010 to 2020. Variables age, comorbidities, and vaccination status were recorded. Vaccine effectiveness was estimated as (1-OR) for intensive care unit (ICU) admission. Statistical significance was established at p < 0.05. A total of 1159 SHLCI-B were registered, of these 68.2% (791) corresponded to the 2017-2018 season; 21.8% (253) were admitted to ICU and 13.8% (160) were exitus; 62.5% (725) cases occurred in those aged >64 years; most frequent risk factor was cardiovascular disease (35.1%, 407) followed by chronic pulmonary obstructive disease-COPD (24.6%, 285) and diabetes (24.1%, 279). In four seasons, the predominant circulating lineage was B/Victoria, in two seasons the B/Yamagata lineage and four seasons had no IBV activity. Four seasons presented discordance with the strain included within the TIV. Vaccine effectiveness (VE) to prevent ICU admission was 31% (95% confidence interval [CI] 4%-51%; p = 0.03); being 29% (95% CI -3% to 51%) in discordant and 43% (95% CI-43% to 77%) in concordant seasons. Significant differences were observed in the number of affected aged > 64 years (odds ratio [OR] = 2.5; 95% CI 1.9-3.4; p < 0.001) and in patients with heart disease (OR = 2.40 95% CI 1.7-3.4; p < 0.001), COPD (OR = 1.6 95% CI 1.1-2.3; p = 0.01), and diabetes (OR = 1.5 95% CI 1.1-2.1; p = 0.04) between discordant and concordant seasons. The increase in hospitalization rate in people> 64 years of age and those presenting comorbidities in seasons with circulating influenza B virus belonging to a lineage discordant with the strain included in the TIV and the decrease of VE to prevent ICU admissions evidence the vital need to administer the quadrivalent influenza vaccine regardless of the findings of predominant circulation in the previous season.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Pulmonary Disease, Chronic Obstructive / Influenza, Human Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Aged / Child / Humans / Middle aged Country/Region as subject: Europa Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.27876

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Pulmonary Disease, Chronic Obstructive / Influenza, Human Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Aged / Child / Humans / Middle aged Country/Region as subject: Europa Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.27876