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Current Opinion on the Therapeutic Capacity of Taurine-Containing Halogen Derivatives in Infectious and Inflammatory Diseases.
Marcinkiewicz, Janusz; Nagl, Markus; Kyriakopoulos, Anthony; Walczewska, Maria; Skóra, Magdalena; Skalska, Paulina.
  • Marcinkiewicz J; Department of Immunology, Jagiellonian University Medical College, Krakow, Poland. janusz.marcinkiewicz@uj.edu.pl.
  • Nagl M; Department of Hygiene, Microbiology and Public Health, Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
  • Kyriakopoulos A; Nasco AD Biotechnology Laboratory, Piraeus, Greece.
  • Walczewska M; Department of Immunology, Jagiellonian University Medical College, Krakow, Poland.
  • Skóra M; Department of Infection Control and Mycology Chair of Microbiology, Jagiellonian University Medical College, Krakow, Poland.
  • Skalska P; Department of Immunology, Jagiellonian University Medical College, Krakow, Poland.
Adv Exp Med Biol ; 1370: 83-98, 2022.
Article in English | MEDLINE | ID: covidwho-1958873
ABSTRACT
Taurine haloamines, N-chlorotaurine (NCT, TauCl), and N-bromotaurine (NBT, TauBr) are formed by a reaction between taurine and hypohalous acids, HOCl and HOBr, respectively. The major source of endogenous taurine haloamines is neutrophils. Both NCT and NBT share strong anti-inflammatory and microbicidal activities supported by an absence of microbial resistance. In the light of these properties, a number of clinical studies have been performed to document their effectiveness in treatment of bacterial, fungal, and viral infections. The administration of NCT and NBT has been limited to topical application, as they are decomposed upon systemic delivery. This review summarizes current knowledge concerning the therapeutic use of NCT and NBT mainly in various skin disorders such as non-healing wounds, acne vulgaris, herpes zoster, and psoriasis. Moreover, the beneficial effect of NCT inhalation in early stages of COVID-19 and other viral respiratory infections is discussed. And finally, we would like to suggest that NCT might be used to inhibit the development of the cytokine storm through its capacity to suppress the production of IL-6.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Communicable Diseases / COVID-19 Drug Treatment Type of study: Prognostic study Limits: Humans Language: English Journal: Adv Exp Med Biol Year: 2022 Document Type: Article Affiliation country: 978-3-030-93337-1_8

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Communicable Diseases / COVID-19 Drug Treatment Type of study: Prognostic study Limits: Humans Language: English Journal: Adv Exp Med Biol Year: 2022 Document Type: Article Affiliation country: 978-3-030-93337-1_8