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Enhanced inflammation and suppressed adaptive immunity in COVID-19 with prolonged RNA shedding.
Tang, Xiaohua; Sun, Rui; Ge, Weigang; Mao, Tingting; Qian, Liujia; Huang, Chongquan; Kang, Zhouyang; Xiao, Qi; Luo, Meng; Zhang, Qiushi; Li, Sainan; Chen, Hao; Liu, Wei; Wang, Bingjie; Li, Shufei; Lin, Xiaoling; Xu, Xueqin; Li, Huanzheng; Wu, Lianpeng; Dai, Jianyi; Gao, Huanhuan; Li, Lu; Lu, Tian; Liang, Xiao; Cai, Xue; Ruan, Guan; Xu, Fei; Li, Yan; Zhu, Yi; Kong, Ziqing; Huang, Jianping; Guo, Tiannan.
  • Tang X; Wenzhou Central Hospital, Dingli Clinical Medical School of Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Sun R; Department of Genetics and genomic medicine, Zhejiang Provincial people's hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China.
  • Ge W; Westlake Intelligent Biomarker Discovery Lab, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.
  • Mao T; School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
  • Qian L; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
  • Huang C; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.
  • Kang Z; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China.
  • Xiao Q; Westlake Intelligent Biomarker Discovery Lab, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.
  • Luo M; School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
  • Zhang Q; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
  • Li S; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.
  • Chen H; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China.
  • Liu W; Westlake Omics (Hangzhou) Biotechnology Co., Ltd., Hangzhou, Zhejiang, China.
  • Wang B; Wenzhou Central Hospital, Dingli Clinical Medical School of Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Li S; Westlake Intelligent Biomarker Discovery Lab, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.
  • Lin X; School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
  • Xu X; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
  • Li H; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.
  • Wu L; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China.
  • Dai J; Wenzhou Central Hospital, Dingli Clinical Medical School of Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Gao H; Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
  • Li L; Calibra Lab in DIAN Diagnostics, Key Laboratory of Digital Technology in Medical Diagnostics of Zhejiang Province, Hangzhou, Zhejiang, China.
  • Lu T; Westlake Intelligent Biomarker Discovery Lab, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.
  • Liang X; School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
  • Cai X; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
  • Ruan G; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.
  • Xu F; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China.
  • Li Y; Westlake Intelligent Biomarker Discovery Lab, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.
  • Zhu Y; School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
  • Kong Z; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
  • Huang J; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.
  • Guo T; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China.
Cell Discov ; 8(1): 70, 2022 Jul 25.
Article in English | MEDLINE | ID: covidwho-1960340
ABSTRACT
Little is known regarding why a subset of COVID-19 patients exhibited prolonged positivity of SARS-CoV-2 infection. Here, we found that patients with long viral RNA course (LC) exhibited prolonged high-level IgG antibodies and higher regulatory T (Treg) cell counts compared to those with short viral RNA course (SC) in terms of viral load. Longitudinal proteomics and metabolomics analyses of the patient sera uncovered that prolonged viral RNA shedding was associated with inhibition of the liver X receptor/retinoid X receptor (LXR/RXR) pathway, substantial suppression of diverse metabolites, activation of the complement system, suppressed cell migration, and enhanced viral replication. Furthermore, a ten-molecule learning model was established which could potentially predict viral RNA shedding period. In summary, this study uncovered enhanced inflammation and suppressed adaptive immunity in COVID-19 patients with prolonged viral RNA shedding, and proposed a multi-omic classifier for viral RNA shedding prediction.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Cell Discov Year: 2022 Document Type: Article Affiliation country: S41421-022-00441-y

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Cell Discov Year: 2022 Document Type: Article Affiliation country: S41421-022-00441-y