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Longitudinal Immune Response to Three Doses of mRNA Vaccine Against COVID-19 in Pediatric Patients Receiving Chemotherapy for Cancer.
Lehrnbecher, Thomas; Sack, Ulrich; Speckmann, Carsten; Groll, Andreas H; Boldt, Andreas; Siebald, Benjamin; Hettmer, Simone; Demmerath, Eva Maria; Schenk, Barbara; Ciesek, Sandra; Klusmann, Jan Henning; Jassoy, Christian; Hoehl, Sebastian.
  • Lehrnbecher T; Division of Pediatric Hematology and Oncology, Hospital for Children and Adolescents, University Hospital, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
  • Sack U; Institute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany.
  • Speckmann C; Division of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.
  • Groll AH; Infectious Disease Research Program, Center for Bone Marrow Transplantation, Department of Pediatric Hematology/Oncology, University Children's Hospital, Muenster, Muenster, Germany.
  • Boldt A; Institute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany.
  • Siebald B; Division of Pediatric Hematology and Oncology, Hospital for Children and Adolescents, University Hospital, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
  • Hettmer S; Division of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.
  • Demmerath EM; Division of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.
  • Schenk B; Institute of Medical Virology, University Hospital Frankfurt, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
  • Ciesek S; Institute of Medical Virology, University Hospital Frankfurt, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
  • Klusmann JH; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
  • Jassoy C; German Center for Infection Research, DZIF, External Partner Site Frankfurt, Braunschweig, Germany.
  • Hoehl S; Division of Pediatric Hematology and Oncology, Hospital for Children and Adolescents, University Hospital, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
Clin Infect Dis ; 2022 Jul 28.
Article in English | MEDLINE | ID: covidwho-2232365
ABSTRACT
Our study in 21 pediatric cancer patients demonstrates that three doses of SARS-CoV-2 mRNA vaccine (BioNTech/Pfizer) elicited both humoral and cellular immunity in most patients during chemotherapy. Immunity was stronger in children with solid tumors and during maintenance therapy compared to those with hematological malignancies or during intensive chemotherapy.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid