Memory B cell development after asymptomatic or mild symptomatic SARS-CoV-2 infection.
J Infect Dis
; 2022 Jul 27.
Article
in English
| MEDLINE | ID: covidwho-2324022
ABSTRACT
BACKGROUND:
The development of memory B cells after asymptomatic SARS-CoV-2 infection is not well understood.METHODS:
We compared Spike antibody titers, pseudovirus neutralizing antibody titers, and memory B cell responses among SARS-CoV-2 PCR positive Marine recruits who either reported asymptomatic or symptomatic infection.RESULTS:
36 asymptomatic participants exhibited similar Spike IgG titers, Spike IgA titers, and pseudovirus neutralization titers compared to 30 symptomatic participants. Pseudovirus neutralization and Spike IgG titers showed significant positive correlations with frequency of memory B cells.CONCLUSIONS:
Among young adults, asymptomatic SARS-CoV-2 infection induced antibody and memory B cell responses comparable to mild symptomatic infection.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Infdis
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