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Memory B cell development after asymptomatic or mild symptomatic SARS-CoV-2 infection.
Kato, Yu; Bloom, Nathaniel I; Sun, Peifang; Balinsky, Corey A; Qiu, Qi; Cheng, Ying; Jani, Vihasi; Schilling, Megan A; Goforth, Carl W; Weir, Dawn L; Ramos, Irene; Sealfon, Stuart C; Letizia, Andrew G; Crotty, Shane.
  • Kato Y; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
  • Bloom NI; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
  • Sun P; Naval Medical Research Center; 503 Robert Grant Ave., Silver Spring, MD 20910, USA.
  • Balinsky CA; Henry Jackson Foundation, Bethesda, MD 20878, USA.
  • Qiu Q; Henry Jackson Foundation, Bethesda, MD 20878, USA.
  • Cheng Y; Leidos, Reston, VA, 20190, USA.
  • Jani V; Henry Jackson Foundation, Bethesda, MD 20878, USA.
  • Schilling MA; Naval Medical Research Center; 503 Robert Grant Ave., Silver Spring, MD 20910, USA.
  • Goforth CW; Naval Medical Research Center; 503 Robert Grant Ave., Silver Spring, MD 20910, USA.
  • Weir DL; Naval Medical Research Center; 503 Robert Grant Ave., Silver Spring, MD 20910, USA.
  • Ramos I; Department of Neurology, Icahn School of Medicine at Mount Sinai;  1 Gustave L. Levy Pl., New York, NY 10029, USA.
  • Sealfon SC; Department of Neurology, Icahn School of Medicine at Mount Sinai;  1 Gustave L. Levy Pl., New York, NY 10029, USA.
  • Letizia AG; Naval Medical Research Center; 503 Robert Grant Ave., Silver Spring, MD 20910, USA.
  • Crotty S; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
J Infect Dis ; 2022 Jul 27.
Article in English | MEDLINE | ID: covidwho-2324022
ABSTRACT

BACKGROUND:

The development of memory B cells after asymptomatic SARS-CoV-2 infection is not well understood.

METHODS:

We compared Spike antibody titers, pseudovirus neutralizing antibody titers, and memory B cell responses among SARS-CoV-2 PCR positive Marine recruits who either reported asymptomatic or symptomatic infection.

RESULTS:

36 asymptomatic participants exhibited similar Spike IgG titers, Spike IgA titers, and pseudovirus neutralization titers compared to 30 symptomatic participants. Pseudovirus neutralization and Spike IgG titers showed significant positive correlations with frequency of memory B cells.

CONCLUSIONS:

Among young adults, asymptomatic SARS-CoV-2 infection induced antibody and memory B cell responses comparable to mild symptomatic infection.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Year: 2022 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Language: English Year: 2022 Document Type: Article Affiliation country: Infdis