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Features of antibody responses after SARS-COV-2 infection in healthcare workers in the first wave of COVID-19 pandemic in Mexico City.
Thompson-Bonilla, Maria Del Rocío; León, Jorge A; Cárdenas-Turrent, Martha Beatriz; Peña-Thompson, Alba; Hanessian-De la Garza, Diana; Zavala-Vega, Sergio; Xicohtencatl-Cortes, Juan; Ochoa, Sara A; Cruz-Córdova, Ariadnna; Arellano-Galindo, José.
  • Thompson-Bonilla MDR; Laboratorio de Medicina Genómica, Hospital Regional "1° de Ocutbre", Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE), Mexico City, Mexico.
  • León JA; Scientific Management of KPC Biotech. California, USA.
  • Cárdenas-Turrent MB; Epidemiología, Hospital Regional "1° de Ocutbre", ISSSTE, Mexico City, Mexico.
  • Peña-Thompson A; Laboratorio de Medicina Genómica, Hospital Regional "1° de Ocutbre", Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE), Mexico City, Mexico.
  • Hanessian-De la Garza D; Medicina Interna, Hospital Regional "1° de Ocutbre", ISSSTE, Mexico City, Mexico.
  • Zavala-Vega S; Laboratorio de Neuropatología, Instituto Nacional de Neurología y Neurocirugía. Manuel Velasco Suarez, Mexico City, Mexico.
  • Xicohtencatl-Cortes J; Laboratorio de Bacteriología Intestinal, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.
  • Ochoa SA; Laboratorio de Bacteriología Intestinal, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.
  • Cruz-Córdova A; Laboratorio de Bacteriología Intestinal, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.
  • Arellano-Galindo J; Unidad de Investigación en Enfermedades Infecciosas, Laboratorio de Virología Clínica y Experimental, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.
J Int Med Res ; 50(7): 3000605221099458, 2022 Jul.
Article in English | MEDLINE | ID: covidwho-1962619
ABSTRACT

OBJECTIVE:

To investigate the antibody response to SARS-CoV-2 and identify associated factors in frontline and second-line healthcare workers (HCWs) at a large hospital in Mexico City during the first wave of COVID-19 pandemic.

METHODS:

This was a cross-sectional study of HCWs returning to work following mandatory isolation after recovering from COVID-19. Immunoglobulin (Ig) M and IgG antibodies elicited by SARS-CoV-2 were semiquantitatively measured using densitometric analysis of band intensities in lateral flow assay (LFA) devices. The mean pixel intensity (dots-per-inch [dpi]) of each band on the LFA was considered a measure of antibody titre.

RESULTS:

Of the 111 HCWs involved in the study, antibody responses were detected in 73/111 (66%) participants. Severe COVID symptoms was associated with old age. No differences in IgM intensity were observed between men and women, but IgG intensity was significantly higher in men than in women. Second-line HCWs produced a higher IgG intensity than firstline HCWs. The IgG intensity was high in severe cases.

CONCLUSIONS:

For HCWs who may acquire SARS-CoV-2 infection, it is necessary to establish a routine program for detection of the virus to avoid risk of infection and spread of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Female / Humans / Male Country/Region as subject: Mexico Language: English Journal: J Int Med Res Year: 2022 Document Type: Article Affiliation country: 03000605221099458

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Female / Humans / Male Country/Region as subject: Mexico Language: English Journal: J Int Med Res Year: 2022 Document Type: Article Affiliation country: 03000605221099458