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Invasive Fungal Diseases in Hospitalized Patients with COVID-19 in Israel: A Multicenter Cohort Study.
Elbaz, Meital; Korem, Maya; Ayalon, Oshrat; Wiener-Well, Yonit; Shachor-Meyouhas, Yael; Cohen, Regev; Bishara, Jihad; Atamna, Alaa; Brosh-Nissimov, Tal; Maaravi, Nir; Nesher, Lior; Chazan, Bibiana; Reisfeld, Sharon; Zimhony, Oren; Chowers, Michal; Maor, Yasmin; Katchman, Eugene; Ben-Ami, Ronen.
  • Elbaz M; Tel Aviv Sourasky Medical Center, Tel Aviv 6997801, Israel.
  • Korem M; Hadassah Medical Center, Jerusalem 9101002, Israel.
  • Ayalon O; Faculty of Medicine, Hebrew University, Jerusalem 9101002, Israel.
  • Wiener-Well Y; Hadassah Medical Center, Jerusalem 9101002, Israel.
  • Shachor-Meyouhas Y; Faculty of Medicine, Hebrew University, Jerusalem 9101002, Israel.
  • Cohen R; Faculty of Medicine, Hebrew University, Jerusalem 9101002, Israel.
  • Bishara J; Shaare Zedek Medical Center, Jerusalem 9101002, Israel.
  • Atamna A; Rambam Medical Center, Haifa 3109601, Israel.
  • Brosh-Nissimov T; Rappaport Faculty of Medicine, Technion, Haifa 3109601, Israel.
  • Maaravi N; Rappaport Faculty of Medicine, Technion, Haifa 3109601, Israel.
  • Nesher L; Laniado Medical Center, Netanya 4290200, Israel.
  • Chazan B; Rabin Medical Medical Center, Petah-Tiqva 4910002, Israel.
  • Reisfeld S; Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
  • Zimhony O; Rabin Medical Medical Center, Petah-Tiqva 4910002, Israel.
  • Chowers M; Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
  • Maor Y; Samson Assuta Ashdod University Hospital, Ashdod 7747629, Israel.
  • Katchman E; Faculty of Health Sciences, Ben Gurion University in the Negev, Beer Sheba 8443944, Israel.
  • Ben-Ami R; Samson Assuta Ashdod University Hospital, Ashdod 7747629, Israel.
J Fungi (Basel) ; 8(7)2022 Jul 09.
Article in English | MEDLINE | ID: covidwho-1964016
ABSTRACT
Highly variable estimates of COVID-19-associated fungal diseases (IFDs) have been reported. We aimed to determine the incidence of clinically important fungal diseases in hospitalized COVID-19 patients during the first year of the pandemic. We performed a multicenter survey of IFDs among patients hospitalized with COVID-19 in 13 hospitals in Israel between February 2020 and May 2021. COVID-19-associated pulmonary mold disease (PMD) and invasive candidiasis (IC) were defined using ECMM/ISHAM and EORTC/MSG criteria, respectively. Overall rates of IC and PMD among patients with critical COVID-19 were 10.86 and 10.20 per 1000 admissions, respectively, with significant variability among medical centers. PMD rates were significantly lower in centers where galactomannan was a send-out test versus centers with on-site testing (p = 0.035). The 30-day mortality rate was 67.5% for IC and 57.5% for PMD. Treatment with an echinocandin for IC or an extended-spectrum azole for PMD was associated with significantly lower mortality rates (adjusted hazard ratio [95% confidence interval], 0.26 [0.07-0.91] and 0.23 [0.093-0.57], respectively). In this multicenter national survey, variable rates of PMD were associated with on-site galactomannan testing, suggesting under-detection in sites lacking this capacity. COVID-19-related IFDs were associated with high mortality rates, which were reduced with appropriate antifungal therapy.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Jof8070721

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Jof8070721