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Cardiac Complications of COVID-19 in Low-Risk Patients.
Srinivasan, Akash; Wong, Felyx; Couch, Liam S; Wang, Brian X.
  • Srinivasan A; Department of Medicine, Faculty of Medicine, Imperial College London, London SW7 2AD, UK.
  • Wong F; Department of Medicine, Faculty of Medicine, Imperial College London, London SW7 2AD, UK.
  • Couch LS; King's College London BHF Centre, The Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK.
  • Wang BX; Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK.
Viruses ; 14(6)2022 06 17.
Article in English | MEDLINE | ID: covidwho-1964105
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic has resulted in over 6 million deaths and significant morbidity across the globe. Alongside common respiratory symptoms, COVID-19 is associated with a variety of cardiovascular complications in the acute and post-acute phases of infection. The suggested pathophysiological mechanisms that underlie these complications include direct viral infection of the myocardium via the angiotensin-converting enzyme 2 (ACE2) protein and a cytokine release syndrome that results in indirect inflammatory damage to the heart. Patients with pre-existing cardiovascular disease and co-morbidities are generally more susceptible to the cardiac manifestations of COVID-19. However, studies have identified a variety of complications in low-risk individuals, including young adults and children. Myocarditis and paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS) are among the adverse events reported in the acute phase of infection. Furthermore, patients have reported cardiac symptoms persisting beyond the acute phase in post-COVID syndrome. This review summarises the acute and chronic cardiac consequences of COVID-19 in low-risk patients, explores the pathophysiology behind them, and discusses new predictive factors for poor outcomes.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Heart Diseases Type of study: Prognostic study Topics: Long Covid Limits: Child / Humans Language: English Year: 2022 Document Type: Article Affiliation country: V14061322

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Heart Diseases Type of study: Prognostic study Topics: Long Covid Limits: Child / Humans Language: English Year: 2022 Document Type: Article Affiliation country: V14061322