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Detection of Ancient Viruses and Long-Term Viral Evolution.
Nishimura, Luca; Fujito, Naoko; Sugimoto, Ryota; Inoue, Ituro.
  • Nishimura L; Human Genetics Laboratory, National Institute of Genetics, Mishima 411-8540, Japan.
  • Fujito N; Department of Genetics, School of Life Science, The Graduate University for Advanced Studies (SOKENDAI), Mishima 411-8540, Japan.
  • Sugimoto R; Human Genetics Laboratory, National Institute of Genetics, Mishima 411-8540, Japan.
  • Inoue I; Department of Genetics, School of Life Science, The Graduate University for Advanced Studies (SOKENDAI), Mishima 411-8540, Japan.
Viruses ; 14(6)2022 06 18.
Article in English | MEDLINE | ID: covidwho-1964110
ABSTRACT
The COVID-19 outbreak has reminded us of the importance of viral evolutionary studies as regards comprehending complex viral evolution and preventing future pandemics. A unique approach to understanding viral evolution is the use of ancient viral genomes. Ancient viruses are detectable in various archaeological remains, including ancient people's skeletons and mummified tissues. Those specimens have preserved ancient viral DNA and RNA, which have been vigorously analyzed in the last few decades thanks to the development of sequencing technologies. Reconstructed ancient pathogenic viral genomes have been utilized to estimate the past pandemics of pathogenic viruses within the ancient human population and long-term evolutionary events. Recent studies revealed the existence of non-pathogenic viral genomes in ancient people's bodies. These ancient non-pathogenic viruses might be informative for inferring their relationships with ancient people's diets and lifestyles. Here, we reviewed the past and ongoing studies on ancient pathogenic and non-pathogenic viruses and the usage of ancient viral genomes to understand their long-term viral evolution.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viruses / COVID-19 Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: V14061336

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viruses / COVID-19 Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: V14061336