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Pulmonary embolism and Covid-19
Cardiology Letters ; 31(3):196-201, 2022.
Article in Slovak | Scopus | ID: covidwho-1964274
ABSTRACT

Aims:

Patients with pulmonary embolism (PE) have different in-hospital mortality rates depending on their comorbidities and the grade of the obstruction of the pulmonary artery. In this study, we observed whether Covid-19 infection had a worsening impact on prognosis in patients affected by PE. We also analysed the significance of known risk factors such as Troponin levels, NT-proBNP levels, D-dimer, arterial blood lactate, and CRP levels in patients with Covid-19 associated PE.

Methods:

In this prospective cohort study, we observed patients hospitalised during the second wave of the Covid-19 pandemic in Trnava. Patients were divided into two groups, 1. patients with covid-19 associated PE (Covid+), and 2. patients with PE without Covid-19 infection as a control group (Covid-). We compared clinical findings, imaging findings, laboratory results and in-hospital mortality between these two groups.

Results:

In this prospective study, we analysed data from 74 patients. Median age of patients was 69.5 (IQR 58-77). We identified 26 (35%) Covid+ patients. Covid+ patients had a longer hospitali-sation [11 (IQR 8-17) days vs 8 (IQR 6.25-10) days, p = 0.004] and significantly higher in-hospital mortality than Covid-group (23% vs 2%, p=0.0065). The combined risk of in-hospital mortality and hemodynamic decompensation was similar in both groups (23% vs 8%, P=0.15). Nonfatal bleeding was reported overall in 4 patients (5.4%) without any significant difference between the two groups (8% vs 4%, p=0,6). From laboratory tests, only NT-proBNP levels had shown the difference between our groups. Despite lower levels of NT-proBNP in Covid + group [300.5 (182-2755.5) vs 1372 (540-5420.5) pg/ml, p = 0.03], mortality rate was higher in these patients.

Conclusion:

The Covid+ group had significantly higher in-hospital mortality, which pointed out the negative impact of Covid-19 infection on patients with PE. Tab. 3, Ref. 12, on-line full text (Free, PDF) www.cardiologyletters.sk. © 2022, SYMEKARD s.r.o.. All rights reserved.
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Full text: Available Collection: Databases of international organizations Database: Scopus Language: Slovak Journal: Cardiology Letters Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: Scopus Language: Slovak Journal: Cardiology Letters Year: 2022 Document Type: Article