Acute kidney injury after Pfizer COVID-19 vaccine due to crescentic fibrillary glomerulonephritis.
Clin Nephrol
; 98(4): 205-208, 2022 Oct.
Article
in English
| MEDLINE | ID: covidwho-1964358
ABSTRACT
Fibrillary glomerulonephritis (FGN) is a rare glomerular disease manifesting with proteinuria, renal impairment, hematuria, hypertension, and in a very small proportion can be associated with rapidly progressive glomerulonephritis and, rarely, crescent formation. The main modality for diagnosis is kidney biopsy, which ultrastructurally demonstrates randomly arranged non-branching mesangial and glomerular basement membrane (GBM) fibrils and positive staining for the biomarker DNAJB9. The pathogenesis is largely unknown. It was previously hypothesized to represent an immune-complex-type glomerulonephritis, as most cases show IgG4 restriction. We present the first case of crescentic FGN after mRNA Pfizer vaccine for COVID-19. A strong temporal association between vaccination, elevated creatinine, and diffuse crescentic fibrillary process was found. Immunological, neoplastic, and infectious causes were ruled out. We hypothesized that the vaccine stimulated an immune response that triggered crescentic FGN, however, further investigations will be needed to elucidate the direct role of COVID-19 vaccination in crescentic glomerular disease.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Glomerulonephritis, Membranoproliferative
/
Acute Kidney Injury
/
COVID-19
/
Glomerulonephritis
Type of study:
Case report
/
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Long Covid
/
Vaccines
Limits:
Humans
Language:
English
Journal:
Clin Nephrol
Year:
2022
Document Type:
Article
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