SARS-Cov2 breakthrough infections in elderly third booster and vaccinated population considered vaccine immune during omicron (B.1.1.529)variant surge in Israel
Current Trends in Biotechnology and Pharmacy
; 16(2):235-252, 2022.
Article
in English
| GIM | ID: covidwho-1964362
ABSTRACT
The fourth booster vaccination was approved in Israel during Omicron (B.1.1.529) variant surge due to increasing SARS-CoV2 breakthrough infections among recently vacci-nated, reasons for this resurgence is not clear. In this Observational study, we analyzed verified SARS-CoV2 infections among over 60 years of age based on vaccination schedule (December 20, 2020-January 29, 2022);infec-tions, severe illness and deaths based on vac-cine immunity (between August 1, 2021-Janu-ary 29, 2022) using Israel COVID-19 dashboard data. There were a total of 214,394 SARS-CoV2 infections (December 20, 2020-Janaury 29, 2022;based vaccination schedule), 165,899 infections;6,267 severe illnesses and 2,031 deaths (August 1, 2021-Janaury 29, 2022) an-alyzed based vaccine immunity among over 60 years old. Vaccination with two doses, main-tained vaccine effectiveness (VE) of 93.2% (95% CI 90-95.5%) for 16 weeks until May 8, 2021 with 14.2% breakthrough infections. When there were no public health restrictions (June-July 2021) partially vaccinated has significantly lower infection rates (X2 [2, N=721]=190.79,p<0.001) with VE of 80.4% (95% CI 69.1-98.3%), while in-fection rates among vaccinated with two doses and unvaccinated are not statistically significant and decline of VE to 6.4% (95% CI -9.9-19.3%) among vaccinated with two doses. After rein-statement of restrictions since July 29, 2021, the VE of vaccinated with two doses improved to 68.0% (95% CI 56.7-76.7%), the third booster showed significantly higher breakthrough infec-tions (26.4%) and a shorter period of 12 weeks effectiveness until October 23, 2021 and by No-vember 20, 2021 the infections rates of vacci-nated with third booster are not statistically bet-ter than partially vaccinated (X2 [1, N=54]=1,85, p=0.17). During the Omicron variant surge, the VE of third booster declined to 42.7% (95% CI 39.9-45.3%) and the infection rates were sig-nificantly higher than vaccinated with two doses (X2[1,N=5898]=8.50, p=0.003) as of January 15, 2022 and subsequently showed improvement in VE to 51.7% (95% CI 50.2-53.2%) and signifi-cantly lower infection rates than vaccinated with two doses (X2[1,N=12380]=98.28, p=<0.001) by January 29, 2022. The vaccinated without valid-ity group (partially vaccinated;past 1-2 doses with expired Green Passes) showed significant-ly lower infection rates (X2 [1, N=15727]=295.3, p<0.001) during December 5,2021-January 29, 2022 period compared to vaccinated with validity (95% of them received third booster dose, and have Green Pass access) group that showed significantly increased infection rates and substantially increased percentages of se-vere illness and deaths.
viral diseases; human diseases; vaccination; coronavirus disease 2019; public health; elderly; immunization; vaccines; disease prevention; health protection; observational studies; severe course; severe infections; death; mortality; immunity; infectious diseases; illness; immune sensitization; acute course; acute infections; Severe acute respiratory syndrome coronavirus 2; man; Israel; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; high income countries; Mediterranean Region; Middle East; very high Human Development Index countries; West Asia; Asia; secondary immunization; SARS-CoV-2; viral infections; aged; elderly people; older adults; senior citizens; death rate; communicable diseases
Full text:
Available
Collection:
Databases of international organizations
Database:
GIM
Topics:
Vaccines
/
Variants
Language:
English
Journal:
Current Trends in Biotechnology and Pharmacy
Year:
2022
Document Type:
Article
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