The effect of metformin use on mortality of COVID-19 patients with diabetes mellitus
Journal of Epidemiology and Public Health
; 7(2):221-231, 2022.
Article
in English
| CAB Abstracts | ID: covidwho-1965028
ABSTRACT
Background:
COVID-19 is a disease caused by infection with the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). COVID-19 is still a worldwide threat because of its high morbidity and mortality. This is influenced by the occurrence of hypertension, obesity, age and diabetes mellitus. However, currently there is still controversy in the results of research regarding the use of metformin in COVID-19 with type 2 diabetes mellitus (type 2 DM). This study was aimed to analyze the effect of metformin in COVID-19 patients with diabetes mellitus on mortality rates. Subjects andMethod:
This study was a systematic review and meta-analysis with the following PICO. P COVID-19 patient with type-2 diabetes mellitus. I administration of metformin therapy. C therapy other than metformin and O mortality. The articles used in this study were obtained from several databases, namely PubMed, Science Direct, Proquest, SpringerLink, Google Scholar and Scopus. The article search keywords were "COVID-19" OR "coronavirus" AND "diabetes" AND "metformin" AND "mortality". Articles included are full-text English using a cohort study design from 2020 to 2021 and reporting the Odds Ratio in multivariate analysis. The selection of articles was carried out using the PRISMA flow chart. The articles were analyzed using the Review Manager 5.3 application.
Non-communicable Human Diseases and Injuries [VV600]; Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210]; Pharmacology [VV730]; human diseases; coronavirus disease 2019; viral diseases; pandemics; public health; metformin; drug therapy; mortality; disease course; prognosis; patients; diabetes mellitus; morbidity; hypertension; type 2 diabetes; age; obesity; systematic reviews; literature reviews; cohort studies; meta-analysis; risk reduction; comorbidity; man; Severe acute respiratory syndrome coronavirus 2; USA; Alabama; France; Spain; China; Korea Republic; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; APEC countries; high income countries; North America; America; OECD Countries; very high Human Development Index countries; East South Central States of USA; Southern States of USA; Gulf States of USA; Southeastern States of USA; European Union Countries; Mediterranean Region; Western Europe; Europe; Southern Europe; East Asia; Asia; high Human Development Index countries; upper-middle income countries; SARS-CoV-2; viral infections; chemotherapy; death rate; disease progression; high blood pressure; fatness; United States of America; People's Republic of China; South Korea
Full text:
Available
Collection:
Databases of international organizations
Database:
CAB Abstracts
Type of study:
Experimental Studies
Language:
English
Journal:
Journal of Epidemiology and Public Health
Year:
2022
Document Type:
Article
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