Advances and challenges in research on SARS-CoV-2 subunit vaccine candidates

ABSTRACT

The Coronavirus Disease 2019 (COVID-19) pand emic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has brought unprecedented pressure on communities, medical systems and economy all over the world. Candidate vaccines have been generated using existing technologies that provides us with the hope to effectively deal with COVID-19. Subunit vaccines are one of the prominent options in the "primer-boost" strategy, and have become the main force in the new candidate vaccines. This paper reviews the latest progress in clinical trials and platforms technology and highlight the challenges encountered in the development of COVID-19 subunit vaccine.