Long-term evaluation of sperm parameters after coronavirus disease 2019 messenger ribonucleic acid vaccination.
F S Rep
; 3(3): 211-213, 2022 Sep.
Article
in English
| MEDLINE | ID: covidwho-2016216
ABSTRACT
Objective:
To determine whether the COVID-19 mRNA vaccines can negatively impact the semen parameters of young healthy men in the long-term.Design:
We conducted semen analyses on 12 men before, 3 and 9 months after achieving fully vaccinated status. Individuals who admitted a history of infertility or previous azoospermia were excluded from study participation.Subjects:
Healthy male volunteers between the ages of 18-50 years old were recruited between September 2021 - March 2022. Main OutcomeMeasures:
Semen analyses were performed and evaluated volume, sperm concentration, total motility, and total motile sperm count (TMSC). The primary outcome was median change in the TMSC at baseline, 3 months, and at least 9 months following vaccination.Results:
A total of 12 men volunteered in our study (median age 26 [25 - 30] years). Subjects provided follow-up semen samples at a median of 10 months following the second vaccine dose. There were no significant changes in any semen parameters between baseline, 3 months, and 10 months following vaccination. Baseline samples demonstrated median sperm concentrations and TMSC of 29.5 million/cc [9.3 - 49] and 31 million [4-51.3], respectively. At 9-month follow-up, sperm concentration and TMSC were 43 [20.5 - 63.5] (P=.351) and 37.5 [8.5 - 117.8] (P=.519), respectively. Of note, there were no significant changes in semen volume nor total motility (%) for participants at follow-up.Conclusion:
COVID-19 mRNA vaccines and the booster dose does not appear to negatively impact the semen parameters of healthy males up to 10 months following vaccination.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Cohort study
/
Experimental Studies
/
Prognostic study
Topics:
Vaccines
Language:
English
Journal:
F S Rep
Year:
2022
Document Type:
Article
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