POST-COVID-19 DISORDERS OF GUT-BRAIN INTERACTION (DGBI): AN INTERNET-BASED EPIDEMIOLOGICAL STUDY
Gastroenterology
; 162(7):S-291-S-292, 2022.
Article
in English
| EMBASE | ID: covidwho-1967287
ABSTRACT
Background:
Post-COVID-19 conditions are defined as new, recurring, or ongoing health issues which present weeks after SARS-CoV-2 infection. The gastrointestinal (GI) involvement of COVID-19 suggests that a group of patients with lingering GI symptoms may develop Post-COVID-19 DGBI including irritable bowel syndrome (IBS) (Schmulson M et al. Am J Gastroenterol. 2021;1164-7). In this study, we aimed to determine the epidemiological features of Post-COVID-19 DGBI.Methods:
Subjects with confirmed COVID-19 at least 6 months before the study who had sustained GI symptoms were invited to complete an internet-based survey on Qualtrics, between March and August 2021. The survey included demographics, acute symptoms, comorbidities, as well as Rome IV questionnaire, Generalized Anxiety Disorder questionnaire (GAD-7) and Patient Health Questionnaire (PHQ)-9 for depression. Data was analyzed using ANOVA and multivariate analysis. Findings were reported as percentage or [p-value;(95% odds ratio CI)].Results:
Overall, 164 subjects (70% female, 14% male, and others unknown) with a positive COVID-19 test completed the survey. Among them, 4% were >65 years old and 24% reported hospitalization. Body mass index ³30 was present in 38%, diabetes in 6.7%, and vitamin D deficiency in 11% of the participants. In total, 108 (66%) subjects fulfilled Rome IV criteria for at least one DGBI. Of 108 with DGBI, only 27 (25%) had DGBI before COVID-19;DGBI developed in 81 subjects after COVID-19. The most common Post-COVID-19 DGBI were functional dyspepsia observed in 38 (postprandial distress syndrome n=31, epigastric pain syndrome n=22) followed by IBS in 26 subjects (IBS with Diarrhea n=7, IBS with Constipation n=4, Mixed-IBS n=14, Unsubtyped IBS n=1) (Table-1). The risk factors of severe COVID-19 including age >65, diabetes, and obesity were not associated with developing Post-COVID- 19 DGBI. Seventy (86%) of subjects with Post-COVID-19 DGBI had at least one GI symptom (abdominal pain, nausea/vomiting, and/or diarrhea) in the acute phase of COVID-19. Nausea/ vomiting during the acute illness increased [p-value of 0.02 with 95% OR CI (0.7-10.4)], and BMI less than 25 also increased the odds [p-value of 0.03 (95% OR CI 0.26-8.4)] for Post-COVID-19 IBS. Anxiety was present in 48% and depression in 65% of subjects with Post-COVID-19 DGBI.Conclusions:
Post-COVID-19 DGBI are new entities associated with a high rate of anxiety and depression. Although the majority of those with Post-COVID-19 DGBI reported having GI symptoms in the acute illness, some appeared in subjects without acute GI symptoms. (Table Presented)
abdominal pain; acute disease; adult; analysis of variance; anxiety; body mass; brain; comorbidity; conference abstract; constipation; controlled study; coronavirus disease 2019; COVID-19 testing; demographics; depression; diabetes mellitus; diarrhea; dyspepsia; enteropathy; epigastric pain syndrome; female; gastrointestinal symptom; generalized anxiety disorder; hospitalization; human; Internet; irritable colon; major clinical study; male; nausea and vomiting; obesity; Patient Health Questionnaire 9; postprandial distress syndrome; questionnaire; risk factor; vitamin D deficiency
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Observational study
Topics:
Long Covid
Language:
English
Journal:
Gastroenterology
Year:
2022
Document Type:
Article
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