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Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy.
Prahl, Mary; Golan, Yarden; Cassidy, Arianna G; Matsui, Yusuke; Li, Lin; Alvarenga, Bonny; Chen, Hao; Jigmeddagva, Unurzul; Lin, Christine Y; Gonzalez, Veronica J; Chidboy, Megan A; Warrier, Lakshmi; Buarpung, Sirirak; Murtha, Amy P; Flaherman, Valerie J; Greene, Warner C; Wu, Alan H B; Lynch, Kara L; Rajan, Jayant; Gaw, Stephanie L.
  • Prahl M; Department of Pediatrics, University of California, San Francisco, CA, USA. mary.prahl@ucsf.edu.
  • Golan Y; Division of Pediatric Infectious Diseases and Global Health, University of California, San Francisco, CA, USA. mary.prahl@ucsf.edu.
  • Cassidy AG; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA.
  • Matsui Y; Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
  • Li L; Gladstone Center for HIV Cure Research, Gladstone Institute, San Francisco, CA, USA.
  • Alvarenga B; Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
  • Chen H; Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
  • Jigmeddagva U; Department of Neurology, University of California, San Francisco, CA, USA.
  • Lin CY; Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
  • Gonzalez VJ; Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
  • Chidboy MA; Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
  • Warrier L; Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
  • Buarpung S; Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
  • Murtha AP; Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
  • Flaherman VJ; Department of Medicine, University of California, San Francisco, CA, USA.
  • Greene WC; Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
  • Wu AHB; Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
  • Lynch KL; Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
  • Rajan J; Department of Pediatrics, University of California, San Francisco, CA, USA.
  • Gaw SL; Gladstone Center for HIV Cure Research, Gladstone Institute, San Francisco, CA, USA.
Nat Commun ; 13(1): 4422, 2022 07 30.
Article in English | MEDLINE | ID: covidwho-1967602
ABSTRACT
Studies are needed to evaluate the safety and effectiveness of mRNA SARS-CoV-2 vaccination during pregnancy, and the levels of protection provided to their newborns through placental transfer of antibodies. Here, we evaluate the transplacental transfer of mRNA vaccine products and functional anti-SARS-CoV-2 antibodies during pregnancy and early infancy in a cohort of 20 individuals vaccinated during late pregnancy. We find no evidence of mRNA vaccine products in maternal blood, placenta tissue, or cord blood at delivery. However, we find time-dependent efficient transfer of IgG and neutralizing antibodies to the neonate that persists during early infancy. Additionally, using phage immunoprecipitation sequencing, we find a vaccine-specific signature of SARS-CoV-2 Spike protein epitope binding that is transplacentally transferred during pregnancy. Timing of vaccination during pregnancy is critical to ensure transplacental transfer of protective antibodies during early infancy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-32188-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-32188-1