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Eosinophil-rich linear IgA bullous dermatosis induced by mRNA COVID-19 booster vaccine.
Nahm, William J; Juarez, Michelle; Wu, Julie; Kim, Randie H.
  • Nahm WJ; The Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, New York, USA.
  • Juarez M; The Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, New York, USA.
  • Wu J; The Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, New York, USA.
  • Kim RH; The Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, New York, USA.
J Cutan Pathol ; 2022 Aug 03.
Article in English | MEDLINE | ID: covidwho-2243640
ABSTRACT
We present a case of eosinophil-rich linear IgA bullous disease (LABD) following the administration of a messenger RNA COVID-19 booster vaccine. A 66-year-old man presented to the emergency department with a 3-week history of a pruritic blistering rash characterized by fluid-filled bullae and multiple annular and polycyclic plaques. He was initially diagnosed with bullous pemphigoid based on a biopsy showing a subepidermal blister with numerous eosinophils. However, direct immunofluorescence studies showed linear IgA and IgM deposition along the basement membrane zone with no immunoreactivity for C3 or IgG. Additionally, indirect immunofluorescence was positive for IgA basement membrane zone antibody. The patient was subsequently diagnosed with LABD and initiated on dapsone therapy with resolution of his lesions at 3-month follow-up. This case illustrates the growing number of autoimmune blistering adverse cutaneous reactions from vaccination. Dermatopathologists should be aware that features of autoimmune blistering diseases can overlap and may not be distinguishable based on these histopathological findings alone. Confirmation with direct immunofluorescence and/or serological studies may be necessary for accurate diagnosis.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Cohort study / Prognostic study Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Cup.14305

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Cohort study / Prognostic study Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Cup.14305