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Impact of antimalarial resistance and COVID-19 pandemic on malaria care among pregnant women in Northern Uganda (ERASE): protocol of a prospective observational study.
Segala, Francesco Vladimiro; Di Gennaro, Francesco; Ictho, Jerry; L'Episcopia, Mariangela; Onapa, Emmanuel; Marotta, Claudia; De Vita, Elda; Amone, James; Iacobelli, Valentina; Ogwang, Joseph; Dall'Oglio, Giovanni; Ngole, Benedict; Murri, Rita; Olal, Lameck; Fantoni, Massimo; Okori, Samuel; Putoto, Giovanni; Severini, Carlo; Lochoro, Peter; Saracino, Annalisa.
  • Segala FV; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy. fvsegala@gmail.com.
  • Di Gennaro F; Department of Biomedical Sciences and Human Oncology, Clinic of Infectious Diseases, University of Bari, Bari, Italy. fvsegala@gmail.com.
  • Ictho J; Department of Biomedical Sciences and Human Oncology, Clinic of Infectious Diseases, University of Bari, Bari, Italy.
  • L'Episcopia M; Doctors with Africa Cuamm, Padua, Italy.
  • Onapa E; Doctors with Africa, CUAMM, Kampala, Uganda.
  • Marotta C; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • De Vita E; St. John's XXIII Hospital Aber, Jaber, Uganda.
  • Amone J; Doctors with Africa Cuamm, Padua, Italy.
  • Iacobelli V; Department of Biomedical Sciences and Human Oncology, Clinic of Infectious Diseases, University of Bari, Bari, Italy.
  • Ogwang J; St. John's XXIII Hospital Aber, Jaber, Uganda.
  • Dall'Oglio G; Department Woman and Child Health Sciences, Catholic University of the Sacred Heart, Rome, Italy.
  • Ngole B; St. John's XXIII Hospital Aber, Jaber, Uganda.
  • Murri R; Doctors with Africa, CUAMM, Kampala, Uganda.
  • Olal L; African Network for Change, Kampala, Uganda.
  • Fantoni M; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
  • Okori S; Dipartimento di Sicurezza e Bioetica-Sezione di Malattie Infettive, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Putoto G; African Network for Change, Kampala, Uganda.
  • Severini C; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
  • Lochoro P; Dipartimento di Sicurezza e Bioetica-Sezione di Malattie Infettive, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Saracino A; St. John's XXIII Hospital Aber, Jaber, Uganda.
BMC Infect Dis ; 22(1): 668, 2022 Aug 04.
Article in English | MEDLINE | ID: covidwho-1968551
ABSTRACT

BACKGROUND:

Uganda accounts for 5% of all malaria cases and deaths reported globally and, in endemic countries, pregnancy is a risk factor for both acquisition of P. falciparum infection and development of severe malaria. In recent years, malaria control has been threatened by COVID-19 pandemic and by the emergence, in Northern Uganda, of both resistance to artemisinin derivatives and to sulfadoxine-pyrimethamine.

METHODS:

In this facility-based, prospective, observational study, pregnant women will be recruited at antenatal-care visits and followed-up until delivery. Collected data will explore the incidence of asymptomatic parasitemia and malaria-related outcomes, as well as the attitudes towards malaria prevention, administration of intermittent preventive treatment, healthcare seeking behavior and use of insecticide-treated nets. A subpopulation of women diagnosed with malaria will be recruited and their blood samples will be analyzed for detection of genetic markers of resistance to artemisinin derivatives and sulfadoxine-pyrimethamine. Also, to investigate the impact of COVID-19 on malaria care among pregnant women, a retrospective, interrupted-time series will be conducted on at the study sites for the period January 2018 to December 2021.

DISCUSSION:

The present study will explore the impact of COVID-19 pandemic on incidence of malaria and malaria-related adverse outcomes, along with the prevalence of resistance to artemisinin derivatives and to sulfadoxine-pyrimethamine. To our knowledge, this is the first study aiming to explore the combined effect of these factors on a cohort of pregnant women. TRIAL REGISTRATION This study has been registered on the ClinicalTrials.gov public website on 26th April, 2022. CLINICALTRIALS gov Identifier NCT05348746.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Malaria, Falciparum / Artemisinins / COVID-19 / Antimalarials Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Female / Humans / Pregnancy Country/Region as subject: Africa Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: S12879-022-07645-3

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Malaria, Falciparum / Artemisinins / COVID-19 / Antimalarials Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Female / Humans / Pregnancy Country/Region as subject: Africa Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: S12879-022-07645-3