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Association Between Previous Stroke and Severe COVID-19: A Retrospective Cohort Study and an Overall Review of Meta-Analysis.
Huang, Huayao; Chen, Junnian; Fang, Shuangfang; Chen, Xiaoling; Pan, Xiaobin; Lei, Hanhan; Zhang, Yixian; Lin, Hailong; Yuan, Qilin; Xia, Pincang; Liu, Nan; Du, Houwei.
  • Huang H; Department of Rehabilitation, Fujian Medical University Union Hospital, Fuzhou, China.
  • Chen J; Department of Critical Care Medicine, Fujian Medical University Union Hospital, Fuzhou, China.
  • Fang S; Department of Neurology, Stroke Research Center, Fujian Medical University Union Hospital, Fuzhou, China.
  • Chen X; Department of Infectious Disease, Fujian Medical University Union Hospital, Fuzhou, China.
  • Pan X; Department of Critical Care Medicine, Fujian Provincial Hospital South Branch, Fuzhou, China.
  • Lei H; Department of Neurology, Stroke Research Center, Fujian Medical University Union Hospital, Fuzhou, China.
  • Zhang Y; Department of Rehabilitation, Fujian Medical University Union Hospital, Fuzhou, China.
  • Lin H; Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, China.
  • Yuan Q; Department of Neurology, Stroke Research Center, Fujian Medical University Union Hospital, Fuzhou, China.
  • Xia P; Fujian Center for Disease Control and Prevention, Fuzhou, China.
  • Liu N; Department of Rehabilitation, Fujian Medical University Union Hospital, Fuzhou, China.
  • Du H; Department of Neurology, Stroke Research Center, Fujian Medical University Union Hospital, Fuzhou, China.
Front Neurol ; 13: 922936, 2022.
Article in English | MEDLINE | ID: covidwho-1969047
ABSTRACT

Objective:

The objective of this study was to investigate the association between previous stroke and the risk of severe coronavirus disease 2019 (COVID-19).

Methods:

We included 164 (61.8 ± 13.6 years) patients with COVID-19 in a retrospective study. We evaluated the unadjusted and adjusted associations between previous stroke and severe COVID-19, using a Cox regression model. We conducted an overall review of systematic review and meta-analysis to investigate the relationship of previous stroke with the unfavorable COVID-19 outcomes.

Results:

The rate of severe COVID-19 in patients with previous stroke was 28.37 per 1,000 patient days (95% confidence interval [CI] 10.65-75.59), compared to 3.94 per 1,000 patient days (95% CI 2.66-5.82) in those without previous stroke (p < 0.001). Previous stroke was significantly associated with severe COVID-19 using a Cox regression model (unadjusted [hazard ratio, HR] 6.98, 95% CI 2.42-20.16, p < 0.001; adjusted HR [per additional 10 years] 4.62, 95% CI 1.52-14.04, p = 0.007). An overall review of systematic review and meta-analysis showed that previous stroke was significantly associated with severe COVID-19, mortality, need for intensive care unit admission, use of mechanical ventilation, and an unfavorable composite outcome.

Conclusion:

Previous stroke seems to influence the course of COVID-19 infection; such patients are at high risk of severe COVID-19 and might benefit from early hospital treatment measures and preventive strategies.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Language: English Journal: Front Neurol Year: 2022 Document Type: Article Affiliation country: Fneur.2022.922936

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Language: English Journal: Front Neurol Year: 2022 Document Type: Article Affiliation country: Fneur.2022.922936