Association Between Previous Stroke and Severe COVID-19: A Retrospective Cohort Study and an Overall Review of Meta-Analysis.
Front Neurol
; 13: 922936, 2022.
Article
in English
| MEDLINE | ID: covidwho-1969047
ABSTRACT
Objective:
The objective of this study was to investigate the association between previous stroke and the risk of severe coronavirus disease 2019 (COVID-19).Methods:
We included 164 (61.8 ± 13.6 years) patients with COVID-19 in a retrospective study. We evaluated the unadjusted and adjusted associations between previous stroke and severe COVID-19, using a Cox regression model. We conducted an overall review of systematic review and meta-analysis to investigate the relationship of previous stroke with the unfavorable COVID-19 outcomes.Results:
The rate of severe COVID-19 in patients with previous stroke was 28.37 per 1,000 patient days (95% confidence interval [CI] 10.65-75.59), compared to 3.94 per 1,000 patient days (95% CI 2.66-5.82) in those without previous stroke (p < 0.001). Previous stroke was significantly associated with severe COVID-19 using a Cox regression model (unadjusted [hazard ratio, HR] 6.98, 95% CI 2.42-20.16, p < 0.001; adjusted HR [per additional 10 years] 4.62, 95% CI 1.52-14.04, p = 0.007). An overall review of systematic review and meta-analysis showed that previous stroke was significantly associated with severe COVID-19, mortality, need for intensive care unit admission, use of mechanical ventilation, and an unfavorable composite outcome.Conclusion:
Previous stroke seems to influence the course of COVID-19 infection; such patients are at high risk of severe COVID-19 and might benefit from early hospital treatment measures and preventive strategies.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Language:
English
Journal:
Front Neurol
Year:
2022
Document Type:
Article
Affiliation country:
Fneur.2022.922936
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