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SARS-CoV-2 Breakthrough Infections: Incidence and Risk Factors in a Large European Multicentric Cohort of Health Workers.
Porru, Stefano; Monaco, Maria Grazia Lourdes; Spiteri, Gianluca; Carta, Angela; Pezzani, Maria Diletta; Lippi, Giuseppe; Gibellini, Davide; Tacconelli, Evelina; Dalla Vecchia, Ilaria; Sala, Emma; Sansone, Emanuele; De Palma, Giuseppe; Bonfanti, Carlo; Lombardo, Massimo; Terlenghi, Luigina; Pira, Enrico; Mansour, Ihab; Coggiola, Maurizio; Ciocan, Catalina; Godono, Alessandro; Tardon, Adonina; Rodriguez-Suarez, Marta-Maria; Fernandez-Tardon, Guillermo; Jimeno-Demuth, Francisco-Jose; Castro-Delgado, Rafael-Vicente; Iglesias Cabo, Tania; Scapellato, Maria Luisa; Liviero, Filippo; Moretto, Angelo; Mason, Paola; Pavanello, Sofia; Volpin, Anna; Vimercati, Luigi; Tafuri, Silvio; De Maria, Luigi; Sponselli, Stefania; Stefanizzi, Pasquale; Caputi, Antonio; Gobba, Fabriziomaria; Modenese, Alberto; Casolari, Loretta; Garavini, Denise; D'Elia, Cristiana; Mariani, Stefania; Filon, Francesca Larese; Cegolon, Luca; Negro, Corrado; Ronchese, Federico; Rui, Francesca; De Michieli, Paola.
  • Porru S; Section of Occupational Medicine, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.
  • Monaco MGL; Occupational Medicine Unit, University Hospital of Verona, 37134 Verona, Italy.
  • Spiteri G; Occupational Medicine Unit, University Hospital of Verona, 37134 Verona, Italy.
  • Carta A; Occupational Medicine Unit, University Hospital of Verona, 37134 Verona, Italy.
  • Pezzani MD; Section of Occupational Medicine, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.
  • Lippi G; Occupational Medicine Unit, University Hospital of Verona, 37134 Verona, Italy.
  • Gibellini D; Infectious Diseases Unit, University Hospital of Verona, 37134 Verona, Italy.
  • Tacconelli E; Section of Clinical Biochemistry, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.
  • Dalla Vecchia I; Section of Microbiology, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.
  • Sala E; Infectious Diseases Unit, University Hospital of Verona, 37134 Verona, Italy.
  • Sansone E; Section of Infectious Diseases, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.
  • De Palma G; Section of Infectious Diseases, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.
  • Bonfanti C; Unit of Occupational Health, Hygiene, Toxicology and Prevention, University Hospital ASST Spedali Civili, 25121 Brescia, Italy.
  • Lombardo M; Unit of Occupational Health and Industrial Hygiene, Department of Medical Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, 25121 Brescia, Italy.
  • Terlenghi L; Unit of Occupational Health, Hygiene, Toxicology and Prevention, University Hospital ASST Spedali Civili, 25121 Brescia, Italy.
  • Pira E; Unit of Occupational Health and Industrial Hygiene, Department of Medical Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, 25121 Brescia, Italy.
  • Mansour I; Department of Molecular and Translational Medicine, Institute of Microbiology, University of Brescia-ASST Spedali Civili, 25121 Brescia, Italy.
  • Coggiola M; Chief Executive Office, ASST Spedali Civili di Brescia, 25121 Brescia, Italy.
  • Ciocan C; Department of Molecular and Translational Medicine, Institute of Microbiology, University of Brescia-ASST Spedali Civili, 25121 Brescia, Italy.
  • Godono A; Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy.
  • Tardon A; Occupational Medicine Unit, University Hospital Città Della Salute e Della Scienza di Torino, 10126 Turin, Italy.
  • Rodriguez-Suarez MM; Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy.
  • Fernandez-Tardon G; Occupational Medicine Unit, University Hospital Città Della Salute e Della Scienza di Torino, 10126 Turin, Italy.
  • Jimeno-Demuth FJ; Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy.
  • Castro-Delgado RV; Occupational Medicine Unit, University Hospital Città Della Salute e Della Scienza di Torino, 10126 Turin, Italy.
  • Iglesias Cabo T; Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy.
  • Scapellato ML; Health Research Institute of Asturias (ISPA), CIBERESP and Public Health Department of the University of Oviedo, Campus del Cristo s/n, 33006 Oviedo, Spain.
  • Liviero F; Health Research Institute of Asturias (ISPA), CIBERESP and Public Health Department of the University of Oviedo, Campus del Cristo s/n, 33006 Oviedo, Spain.
  • Moretto A; Health Research Institute of Asturias (ISPA), CIBERESP and Public Health Department of the University of Oviedo, Campus del Cristo s/n, 33006 Oviedo, Spain.
  • Mason P; Health Research Institute of Asturias (ISPA), CIBERESP and Public Health Department of the University of Oviedo, Campus del Cristo s/n, 33006 Oviedo, Spain.
  • Pavanello S; Health Research Institute of Asturias (ISPA), CIBERESP and Public Health Department of the University of Oviedo, Campus del Cristo s/n, 33006 Oviedo, Spain.
  • Volpin A; Health Research Institute of Asturias (ISPA), CIBERESP and Public Health Department of the University of Oviedo, Campus del Cristo s/n, 33006 Oviedo, Spain.
  • Vimercati L; Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.
  • Tafuri S; University Hospital of Padova, 35128 Padova, Italy.
  • De Maria L; Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.
  • Sponselli S; University Hospital of Padova, 35128 Padova, Italy.
  • Stefanizzi P; Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.
  • Caputi A; University Hospital of Padova, 35128 Padova, Italy.
  • Gobba F; Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.
  • Modenese A; University Hospital of Padova, 35128 Padova, Italy.
  • Casolari L; Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.
  • Garavini D; University Hospital of Padova, 35128 Padova, Italy.
  • D'Elia C; University Hospital of Padova, 35128 Padova, Italy.
  • Mariani S; Interdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.
  • Filon FL; Interdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.
  • Cegolon L; Interdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.
  • Negro C; Interdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.
  • Ronchese F; Interdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.
  • Rui F; Interdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.
  • De Michieli P; Department of Biomedical, Metabolic and Neural Sciences, University of Modena & Reggio Emilia, 41125 Modena, Italy.
Vaccines (Basel) ; 10(8)2022 Jul 27.
Article in English | MEDLINE | ID: covidwho-1969521
ABSTRACT

BACKGROUND:

The research aimed to investigate the incidence of SARS-CoV-2 breakthrough infections and their determinants in a large European cohort of more than 60,000 health workers.

METHODS:

A multicentric retrospective cohort study, involving 12 European centers, was carried out within the ORCHESTRA project, collecting data up to 18 November 2021 on fully vaccinated health workers. The cumulative incidence of SARS-CoV-2 breakthrough infections was investigated with its association with occupational and social-demographic characteristics (age, sex, job title, previous SARS-CoV-2 infection, antibody titer levels, and time from the vaccination course completion).

RESULTS:

Among 64,172 health workers from 12 European health centers, 797 breakthrough infections were observed (cumulative incidence of 1.2%). The primary analysis using individual data on 8 out of 12 centers showed that age and previous infection significantly modified breakthrough infection rates. In the meta-analysis of aggregated data from all centers, previous SARS-CoV-2 infection and the standardized antibody titer were inversely related to the risk of breakthrough infection (p = 0.008 and p = 0.007, respectively).

CONCLUSION:

The inverse correlation of antibody titer with the risk of breakthrough infection supports the evidence that vaccination plays a primary role in infection prevention, especially in health workers. Cellular immunity, previous clinical conditions, and vaccination timing should be further investigated.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study / Reviews Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Vaccines10081193

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study / Reviews Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Vaccines10081193