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Molecular biological characteristics of the 2019 novel Coronavirus in Shijiazhuang
Chinese Journal of Laboratory Medicine ; 45(6):637-641, 2022.
Article in Chinese | EMBASE | ID: covidwho-1969574
ABSTRACT
Objective To analyze the molecular epidemiological characteristics of the Corona virus disease 2019 (COVID‑19) cases in Shijiazhuang, which can reveal the origin of the outbreak and provide a scientific basis for COVID‑19 prevention and control. Methods From January 2 to January 8, 2021, a total of 404 samples from 170 COVID‑19 cases were collected from the Shijiazhuang Fifth Hospital. The consensus sequence of 2019 novel Coronavirus(2019‑nCoV) was obtained through multiplex polymerase chain reaction‑based sequencing. The sequences of 170 COVID‑19 cases were analyzed by the PANGOLIN, and the data were statistically analyzed by T‑test. Results Among the 404 COVID‑19 samples, a total of 356 samples obtained high quality genome sequences (>95%, 100×sequencing depth). The whole genome sequences of 170 COVID‑19 cases were obtained by eliminating repeated samples. All 170 sequences were recognized as lineage B1.1 using PANGOLIN. The number of single nucleotide polymorphism arrange from 18-22 and most of the single nucleotide polymorphism were synonymous variants. All of 170 genomes could be classified into 48 sub‑groups and most of the genomes were classified into 2 sub‑groups (66 and 31, respectively). Conclusions All cases in this study are likely originated from one imported case. The viruses have spread in the community for a long time and have mutated during the community transmission.
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Full text: Available Collection: Databases of international organizations Database: EMBASE Language: Chinese Journal: Chinese Journal of Laboratory Medicine Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Language: Chinese Journal: Chinese Journal of Laboratory Medicine Year: 2022 Document Type: Article