Overview Of Immune Response to the COVID-19 Vaccination Among Hemodialysis Patients

ABSTRACT

Globally, over 100 million confirmed cases of COVID-19 have been reported. The virus that causes COVID-19 is designated SARS-CoV-2;previously, it was referred to as 2019-nCoV. At the end of 2019, cases have been reported in all continents. The main aim of the COVID-19 vaccine is to establish immunity to the spike protein of SARS-CoV-2. Immune system dysfunction is one of the serious complications of chronic kidney disease (CKD). On the other hand, the immune system has a central role in the initiation and progression of this disease by promoting and persistence of systemic inflammation. Patients with end stage renal disease (ESRD) are particularly vulnerable to severe COVID-19 due to the older age and high frequency of comorbidity, such as diabetes and hypertension, in this population. This study aimed to review the immune response following vaccination with the COVID-19 vaccines in patients on maintenance HD and the factors associated with it.