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T cell responses to adenoviral vectors expressing the SARS-CoV-2 nucleoprotein.
Hasanpourghadi, Mohadeseh; Novikov, Mikhail; Ambrose, Robert; Chekaoui, Arezki; Newman, Dakota; Zhou, Xiang Yang; Ertl, Hildegund C J.
  • Hasanpourghadi M; The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA, 1-215-898-3863.
  • Novikov M; The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA, 1-215-898-3863.
  • Ambrose R; The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA, 1-215-898-3863.
  • Chekaoui A; The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA, 1-215-898-3863.
  • Newman D; The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA, 1-215-898-3863.
  • Zhou XY; The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA, 1-215-898-3863.
  • Ertl HCJ; The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA, 1-215-898-3863.
Curr Trends Microbiol ; 15: 1-28, 2021.
Article in English | MEDLINE | ID: covidwho-1970504
ABSTRACT
SARS-CoV-2 vaccines aim to protect against COVID-19 through neutralizing antibodies against the viral spike protein. Mutations within the spike's receptor-binding domain may eventually reduce vaccine efficacy, necessitating periodic updates. Vaccine-induced immunity could be broadened by adding T cell-inducing antigens such as SARS-CoV-2's nucleoprotein (N). Here we describe two replication-defective chimpanzee adenovirus (AdC) vectors from different serotypes expressing SARS-CoV-2 N either in its wild-type form or fused into herpes simplex virus glycoprotein D (gD), an inhibitor of an early T cell checkpoint. The vaccines induce potent and sustained CD8+ T cell responses that are broadened upon inclusion of gD. Depending on the vaccine regimen booster immunizations increase magnitude and breadth of T cell responses. Epitopes that are recognized by the vaccine-induced T cells are highly conserved among global SARS-CoV-2 isolates indicating that addition of N to COVID-19 vaccines may lessen the risk of loss of vaccine-induced protection due to variants.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines / Variants Language: English Journal: Curr Trends Microbiol Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines / Variants Language: English Journal: Curr Trends Microbiol Year: 2021 Document Type: Article