Antimicrobial activity of clioquinol and nitroxoline: a scoping review.
Arch Microbiol
; 204(8): 535, 2022 Jul 30.
Article
in English
| MEDLINE | ID: covidwho-1971673
ABSTRACT
Clioquinol and nitroxoline, two drugs with numerous pharmacological properties fallen into disuse for many decades. The first was considered dangerous due to contraindications and the second mainly because was taken as ineffective, despite its known antibacterial activity. In the last decades, the advances in pharmaceutical chemistry, molecular biology, toxicology and genetics allowed to better understand the cellular action of these compounds, some toxicological issues and/or activity scopes. Thus, a new opportunity for these drugs to be considered as potential antimicrobial agents has arisen. This review contemplates the trajectory of clioquinol and nitroxoline from their emergence to the present day, emphasizing the new studies that indicate the possibility of reintroduction for specific cases.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Clioquinol
/
Anti-Infective Agents
/
Nitroquinolines
Type of study:
Reviews
Language:
English
Journal:
Arch Microbiol
Year:
2022
Document Type:
Article
Affiliation country:
S00203-022-03122-2
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