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COVID-19 patients with altered steroid hormone levels are more likely to have higher disease severity.
Sezer, Sevilay; Bal, Ceylan; Kalem, Ayse Kaya; Kayaaslan, Bircan; Eser, Fatma; Hasanoglu, Imran; Akinci, Esragül; Güner, Rahmet; Erel, Özcan; Yilmaz, Gülsen.
  • Sezer S; Department of Medical Biochemistry, Ankara City Hospital, Ankara, Turkey. sevilaysezer@gmail.com.
  • Bal C; Department of Medical Biochemistry, Ankara City Hospital, Ankara, Turkey.
  • Kalem AK; Department of Medical Biochemistry, Ankara Yildirim Beyazit University, Faculty of Medicine, Ankara, Turkey.
  • Kayaaslan B; Department of Infectious Diseases and Clinical Microbiology, Ankara City Hospital, Ankara Yildirim Beyazit University, Faculty of Medicine, Ankara, Turkey.
  • Eser F; Department of Infectious Diseases and Clinical Microbiology, Ankara City Hospital, Ankara Yildirim Beyazit University, Faculty of Medicine, Ankara, Turkey.
  • Hasanoglu I; Department of Infectious Diseases and Clinical Microbiology, Ankara City Hospital, Ankara Yildirim Beyazit University, Faculty of Medicine, Ankara, Turkey.
  • Akinci E; Department of Infectious Diseases and Clinical Microbiology, Ankara City Hospital, Ankara Yildirim Beyazit University, Faculty of Medicine, Ankara, Turkey.
  • Güner R; Department of Infectious Diseases and Clinical Microbiology, Health Sciences University, Ankara City Hospital, Ankara, Turkey.
  • Erel Ö; Department of Infectious Diseases and Clinical Microbiology, Ankara City Hospital, Ankara Yildirim Beyazit University, Faculty of Medicine, Ankara, Turkey.
  • Yilmaz G; Department of Medical Biochemistry, Ankara City Hospital, Ankara, Turkey.
Endocrine ; 78(2): 373-379, 2022 11.
Article in English | MEDLINE | ID: covidwho-1971835
ABSTRACT

PURPOSE:

This study aims to evaluate the correlations between the severity of the disease and serum steroid levels by analyzing the serum steroid levels in COVID-19 patients with different levels of disease progression and the control group.

METHODS:

Morning serum Aldosterone, 11-deoxycortisol, Androstenedione, 17-hydroxyprogesterone, Dihydrotestosterone (DHT), Dehydroepiandrosterone (DHEA), Corticosterone, Dehydroepiandrosterone sulfate (DHEAS), Estrone, Estradiol, Progesterone, 11-deoxycorticosterone, Cortisol, Corticosterone, Androsterone, Pregnenolone, 17-hydroxypregnenolone and 21-deoxycortisol levels were measured in 153 consecutive patients were grouped as mild, moderate, and severe based on the WHO COVID-19 disease severity classification and the control group. Steroid hormone levels were analyzed at once with a liquid chromatography-tandem mass spectrometric method (LC-MS/MS).

RESULTS:

In our study, nearly all steroids were statistically significantly higher in the patients' group than in the control group (p < 0.001). Also, DHEA was an independent indicator of the disease severity with COVID-19

CONCLUSIONS:

Our study reveals that the alteration in steroid hormone levels was correlated with disease severity. Also, steroid hormone levels should be followed up during COVID-19 disease management.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cortodoxone / COVID-19 Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Journal: Endocrine Journal subject: Endocrinology Year: 2022 Document Type: Article Affiliation country: S12020-022-03140-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cortodoxone / COVID-19 Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Journal: Endocrine Journal subject: Endocrinology Year: 2022 Document Type: Article Affiliation country: S12020-022-03140-6