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Antimicrobial strategy for targeted elimination of different microbes, including bacterial, fungal and viral pathogens.
Mitsunaga, Makoto; Ito, Kimihiro; Nishimura, Takashi; Miyata, Hironori; Miyakawa, Kei; Morita, Takeshi; Ryo, Akihide; Kobayashi, Hisataka; Mizunoe, Yoshimitsu; Iwase, Tadayuki.
  • Mitsunaga M; Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan. mit@jikei.ac.jp.
  • Ito K; Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
  • Nishimura T; Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
  • Miyata H; Animal Research Center, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
  • Miyakawa K; Department of Microbiology, Yokohama City University School of Medicine, Kanagawa, Japan.
  • Morita T; Department of Microbiology, Yokohama City University School of Medicine, Kanagawa, Japan.
  • Ryo A; Department of Microbiology, Yokohama City University School of Medicine, Kanagawa, Japan.
  • Kobayashi H; Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
  • Mizunoe Y; The Jikei University School of Medicine, Tokyo, Japan.
  • Iwase T; Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan. iwase.tadayuki@jikei.ac.jp.
Commun Biol ; 5(1): 647, 2022 07 04.
Article in English | MEDLINE | ID: covidwho-1972668
ABSTRACT
The continuous emergence of microbial pathogens for which there are no effective antimicrobials threatens global health, necessitating novel antimicrobial approaches. Here, we present a targeted antimicrobial strategy that can be applied to various microbial pathogens. A photoimmuno-conjugate composed of an antibody against the target pathogen and a photoplastic phthalocyanine-derivative probe that generates photo-induced mechanical stress was developed based on photoimmuno-technology. This strategy, named as photoimmuno-antimicrobial strategy (PIAS), eliminates targeted pathogens, regardless of the target species or drug-resistance status. Specifically, PIAS acts on a broad range of microbes, including the bacterial pathogen Staphylococcus aureus, fungal pathogen Candida albicans, including their drug-resistant strains, and viral pathogen SARS-CoV-2, the causative agent of COVID-19. Furthermore, PIAS protects mice from fatal infections without damaging the non-targeted host microbiota and tissues. This study may contribute to the development of next-generation anti-infective therapies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Drug Treatment / Anti-Infective Agents Limits: Animals Language: English Journal: Commun Biol Year: 2022 Document Type: Article Affiliation country: S42003-022-03586-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Drug Treatment / Anti-Infective Agents Limits: Animals Language: English Journal: Commun Biol Year: 2022 Document Type: Article Affiliation country: S42003-022-03586-4