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Vaccines against SARS-CoV-2 variants and future pandemics.
Park, Taeyoung; Hwang, Hyogyeong; Moon, Suhyeong; Kang, Sang Gu; Song, Seunghyup; Kim, Young Hun; Kim, Hanbi; Ko, Eun-Ju; Yoon, Soon-Do; Kang, Sang-Moo; Hwang, Hye Suk.
  • Park T; Department of Biology, College of Life Science and Industry, Sunchon National University (SCNU), Suncheon, South Korea.
  • Hwang H; Department of Biology, College of Life Science and Industry, Sunchon National University (SCNU), Suncheon, South Korea.
  • Moon S; Department of Biology, College of Life Science and Industry, Sunchon National University (SCNU), Suncheon, South Korea.
  • Kang SG; Department of Biology, College of Life Science and Industry, Sunchon National University (SCNU), Suncheon, South Korea.
  • Song S; Department of Biology, College of Life Science and Industry, Sunchon National University (SCNU), Suncheon, South Korea.
  • Kim YH; Department of Biology, College of Life Science and Industry, Sunchon National University (SCNU), Suncheon, South Korea.
  • Kim H; Department of Biology, College of Life Science and Industry, Sunchon National University (SCNU), Suncheon, South Korea.
  • Ko EJ; College of Veterinary Medicine and Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju, South Korea.
  • Yoon SD; Department of Chemical and Biomolecular Engineering, Chonnam National University, Yeosu, South Korea.
  • Kang SM; Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.
  • Hwang HS; Department of Biology, College of Life Science and Industry, Sunchon National University (SCNU), Suncheon, South Korea.
Expert Rev Vaccines ; 21(10): 1363-1376, 2022 10.
Article in English | MEDLINE | ID: covidwho-2275691
ABSTRACT

INTRODUCTION:

Vaccination continues to be the most effective method for controlling COVID-19 infectious diseases. Nonetheless, SARS-CoV-2 variants continue to evolve and emerge, resulting in significant public concerns worldwide, even after more than 2 years since the COVID-19 pandemic. It is important to better understand how different COVID-19 vaccine platforms work, why SARS-CoV-2 variants continue to emerge, and what options for improving COVID-19 vaccines can be considered to fight against SARS-CoV-2 variants and future pandemics. AREA COVERED Here, we reviewed the innate immune sensors in the recognition of SARS-CoV-2 virus, innate and adaptive immunity including neutralizing antibodies by different COVID-19 vaccines. Efficacy comparison of the several COVID-19 vaccine platforms approved for use in humans, concerns about SARS-CoV-2 variants and breakthrough infections, and the options for developing future COIVD-19 vaccines were also covered. EXPERT OPINION Owing to the continuous emergence of novel pathogens and the reemergence of variants, safer and more effective new vaccines are needed. This review also aims to provide the knowledge basis for the development of next-generation COVID-19 and pan-coronavirus vaccines to provide cross-protection against new SARS-CoV-2 variants and future coronavirus pandemics.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / COVID-19 Type of study: Observational study / Randomized controlled trials Topics: Vaccines / Variants Limits: Humans Language: English Journal: Expert Rev Vaccines Journal subject: Allergy and Immunology Year: 2022 Document Type: Article Affiliation country: 14760584.2022.2110075

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / COVID-19 Type of study: Observational study / Randomized controlled trials Topics: Vaccines / Variants Limits: Humans Language: English Journal: Expert Rev Vaccines Journal subject: Allergy and Immunology Year: 2022 Document Type: Article Affiliation country: 14760584.2022.2110075