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Viral Load Dynamics in SARS-CoV-2 Omicron Breakthrough Infections.
Dewald, Felix; Detmer, Susanne; Pirkl, Martin; Hellmich, Martin; Heger, Eva; Herrmann, Maximilian; Lehmann, Clara; Zweigner, Janine; Klein, Florian.
  • Dewald F; Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Detmer S; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
  • Pirkl M; Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Hellmich M; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
  • Heger E; Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Herrmann M; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Lehmann C; Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Zweigner J; Department of Hospital Hygiene and Infection Control, University Hospital of Cologne, Cologne, Germany.
  • Klein F; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
J Infect Dis ; 226(10): 1721-1725, 2022 Nov 11.
Article in English | MEDLINE | ID: covidwho-1973170
ABSTRACT
To determine viral dynamics in Omicron breakthrough infections, we measured severe acute respiratory syndrome coronavirus 2 RNA in 206 double-vaccinated or boostered individuals. During the first 3 days following the onset of symptoms, viral loads were significantly higher (cycle threshold [Ct], 21.76) in vaccinated compared to boostered (Ct, 23.14) individuals (P = .029). However, by performing a longitudinal analysis on 32 individuals over 14 days, no difference in the viral load trajectory was observed between double-vaccinated and boostered patients. Our results indicate that booster immunization results in a reduction in detectable viral loads without significantly changing viral load dynamics over time.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Prognostic study Topics: Vaccines / Variants Limits: Humans Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Prognostic study Topics: Vaccines / Variants Limits: Humans Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis