Clostridioides difficile co-infection in patients with COVID-19.
Future Microbiol
; 17: 653-663, 2022 06.
Article
in English
| MEDLINE | ID: covidwho-1974548
ABSTRACT
Aim:
To assess the impact of Clostridioides difficile infection on the course of COVID-19.Methods:
The authors included 809 patients with COVID-19 in this retrospective study 55 had C. difficile infection, 23 had C. difficile-negative antibiotic-associated diarrhea and 731 had no diarrhea. C. difficile in feces was determined by immunochromatographic test for its toxins.Results:
C. difficile infection was associated with increased risk of death (hazard ratio = 2.6; p = 0.021), especially after 20 days of disease (hazard ratio = 6.5; p < 0.001). C. difficile infection-associated diarrhea was longer and more severe than C. difficile-negative antibiotic-associated diarrhea. Unlike patients with C. difficile-negative antibiotic-associated diarrhea, patients with C. difficile infection were admitted to the intensive care unit and needed mechanical ventilation more often than those without diarrhea.Conclusion:
C. difficile infection worsens the course and prognosis of COVID-19.
Patients with COVID-19 usually receive antibiotic treatment, which predisposes them to antibiotic-associated diarrhea. In some cases, antibiotic-associated diarrhea can be caused by Clostridioides difficile bacteria. To learn more about the impact of C. difficile infection on COVID-19, the authors analyzed data from the medical records of 809 patients with COVID-19. The authors found that C. difficile co-infection worsens the course and prognosis of COVID-19. The authors suggest that patients with COVID-19 who develop diarrhea after taking antibiotics be tested for C. difficile and treated for this co-infection if the test is positive.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Clostridioides difficile
/
Clostridium Infections
/
Coinfection
/
COVID-19
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Future Microbiol
Journal subject:
Microbiology
Year:
2022
Document Type:
Article
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