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COVID-19 cases, hospitalizations and deaths after vaccination: a cohort event monitoring study, Islamic Republic of Iran.
Hosseinzadeh, Ali; Sahab-Negah, Sajad; Nili, Sairan; Aliyari, Roqayeh; Goli, Shahrbanoo; Fereidouni, Mohammad; Alami, Ali; Shati, Mohsen; Ahmadnezhad, Elham; Mehravaran, Shiva; Fateh, Mansooreh; Khajeha, Hamidreza; Emamian, Zahra; Behmanesh, Elahe; Mahdavi, Sepideh; Enayatrad, Mostafa; Mangolian Shahrbabaki, Parvin; Ansari-Moghaddam, Alireza; Heidarzadeh, Abtin; Shahraki-Sanavi, Fariba; Hashemi Shahri, Seyed Mohammad; Dehghan, Mahlagha; Amini Moridani, Mohammadreza; Sheibani, Hossein; Abbaszadeh, Maryam; Jafari, Reza; Valikhani, Maryam; Binesh, Ehsan; Vahedi, Hamid; Chaman, Reza; Khodashahi, Rozita; Amini, Mahnaz; Jabbari Azad, Farahzad; Rezaeitalab, Fariborz; Amel Jamehdar, Saeid; Eshraghi, Ali; Sharifi, Hamid; Hashemi Bajgani, Seyed Mehdi; Mahdavi, Amin; Jafarzadeh, Abdollah; Farokhnia, Mehrdad; Ebrahimi, Saeedeh; Pardakhti, Abbas; Ghaderi, Ebrahim; Soltani, Hasan; Jadidoleslami, Sedigh; Arianejad, Anoush; Gavili, Hamed; Moradveisi, Borhan; Motamedi, Dina.
  • Hosseinzadeh A; School of Public Health, Shahroud University of Medical Sciences, Shahroud, Islamic Republic of Iran.
  • Sahab-Negah S; Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
  • Nili S; Faculty of Health, Kurdistan University of Medical Sciences, Sanandaj, Islamic Republic of Iran.
  • Aliyari R; Ophthalmic Epidemiology Research Center, 7 Tir Square, Shahroud University of Medical Sciences, Shahroud 3614773947, Islamic Republic of Iran.
  • Goli S; School of Public Health, Shahroud University of Medical Sciences, Shahroud, Islamic Republic of Iran.
  • Fereidouni M; Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Islamic Republic of Iran.
  • Alami A; Social Determinants of Health Research Center, Gonabad University of Medical Sciences, Gonabad, Islamic Republic of Iran.
  • Shati M; Department of Epidemiology, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran.
  • Ahmadnezhad E; National Institute for Health Research, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
  • Mehravaran S; School of Computer Mathematics and Natural Sciences, Morgan State University, Baltimore, United States of America.
  • Fateh M; Center for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Islamic Republic of Iran.
  • Khajeha H; Ophthalmic Epidemiology Research Center, 7 Tir Square, Shahroud University of Medical Sciences, Shahroud 3614773947, Islamic Republic of Iran.
  • Emamian Z; Health Technology Incubator Center, Shahroud University of Medical Sciences, Shahroud, Islamic Republic of Iran.
  • Behmanesh E; Health Technology Incubator Center, Shahroud University of Medical Sciences, Shahroud, Islamic Republic of Iran.
  • Mahdavi S; School of Public Health, Shahroud University of Medical Sciences, Shahroud, Islamic Republic of Iran.
  • Enayatrad M; Bahar Clinical Research Development Unit, Shahroud University of Medical Sciences, Shahroud, Islamic Republic of Iran.
  • Mangolian Shahrbabaki P; Razi Faculty of Nursing and Midwifery, Kerman University of Medical Sciences, Kerman, Islamic Republic of Iran.
  • Ansari-Moghaddam A; Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Islamic Republic of Iran.
  • Heidarzadeh A; School of Medicine, Guilan University of Medical Sciences, Rasht, Islamic Republic of Iran.
  • Shahraki-Sanavi F; Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Islamic Republic of Iran.
  • Hashemi Shahri SM; Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Islamic Republic of Iran.
  • Dehghan M; Razi Faculty of Nursing and Midwifery, Kerman University of Medical Sciences, Kerman, Islamic Republic of Iran.
  • Amini Moridani M; Vice-Chancellery for Health Affairs, Guilan University of Medical Sciences, Rasht, Islamic Republic of Iran.
  • Sheibani H; Imam Hossein Clinical Research Development Unit, Shahroud University of Medical Sciences, Shahroud, Islamic Republic of Iran.
  • Abbaszadeh M; Imam Hossein Clinical Research Development Unit, Shahroud University of Medical Sciences, Shahroud, Islamic Republic of Iran.
  • Jafari R; School of Allied Medical Sciences, Shahroud University of Medical Sciences, Shahroud, Islamic Republic of Iran.
  • Valikhani M; Imam Hossein Clinical Research Development Unit, Shahroud University of Medical Sciences, Shahroud, Islamic Republic of Iran.
  • Binesh E; Imam Hossein Clinical Research Development Unit, Shahroud University of Medical Sciences, Shahroud, Islamic Republic of Iran.
  • Vahedi H; Imam Hossein Clinical Research Development Unit, Shahroud University of Medical Sciences, Shahroud, Islamic Republic of Iran.
  • Chaman R; School of Public Health, Shahroud University of Medical Sciences, Shahroud, Islamic Republic of Iran.
  • Khodashahi R; Department of Infectious Diseases and Tropical Medicine, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
  • Amini M; Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
  • Jabbari Azad F; Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
  • Rezaeitalab F; Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
  • Amel Jamehdar S; Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
  • Eshraghi A; Department of Cardiology, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
  • Sharifi H; HIV/STI Surveillance Research Center, Kerman University of Medical Sciences, Kerman, Islamic Republic of Iran.
  • Hashemi Bajgani SM; Department of Internal Medicine, Kerman University of Medical Sciences, Kerman, Islamic Republic of Iran.
  • Mahdavi A; Cardiovascular Research Centre, Kerman University of Medical Sciences, Kerman, Islamic Republic of Iran.
  • Jafarzadeh A; School of Public Health, Shahroud University of Medical Sciences, Shahroud, Islamic Republic of Iran.
  • Farokhnia M; Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
  • Ebrahimi S; School of Public Health, Shahroud University of Medical Sciences, Shahroud, Islamic Republic of Iran.
  • Pardakhti A; Faculty of Health, Kurdistan University of Medical Sciences, Sanandaj, Islamic Republic of Iran.
  • Ghaderi E; School of Public Health, Shahroud University of Medical Sciences, Shahroud, Islamic Republic of Iran.
  • Soltani H; Ophthalmic Epidemiology Research Center, 7 Tir Square, Shahroud University of Medical Sciences, Shahroud 3614773947, Islamic Republic of Iran.
  • Jadidoleslami S; School of Public Health, Shahroud University of Medical Sciences, Shahroud, Islamic Republic of Iran.
  • Arianejad A; Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Islamic Republic of Iran.
  • Gavili H; School of Public Health, Shahroud University of Medical Sciences, Shahroud, Islamic Republic of Iran.
  • Moradveisi B; Social Determinants of Health Research Center, Gonabad University of Medical Sciences, Gonabad, Islamic Republic of Iran.
  • Motamedi D; School of Public Health, Shahroud University of Medical Sciences, Shahroud, Islamic Republic of Iran.
Bull World Health Organ ; 100(8): 474-483, 2022 Aug 01.
Article in English | MEDLINE | ID: covidwho-1974569
ABSTRACT

Objective:

To investigate the incidence of coronavirus disease 2019 (COVID-19) cases, hospitalizations and deaths in Iranians vaccinated with either AZD1222 Vaxzevria, CovIran® vaccine, SARS-CoV-2 Vaccine (Vero Cell), Inactivated (lnCoV) or Sputnik V.

Methods:

We enrolled individuals 18 years or older receiving their first COVID-19 vaccine dose between April 2021 and January 2022 in seven Iranian cities. Participants completed weekly follow-up surveys for 17 weeks (25 weeks for AZD1222) to report their COVID-19 status and hospitalization. We used Cox regression models to assess risk factors for contracting COVID-19, hospitalization and death.

Findings:

Of 89 783 participants enrolled, incidence rates per 1 000 000 person-days were 528.2 (95% confidence interval, CI 514.0-542.7) for contracting COVID-19; 55.8 (95% CI 51.4-60.5) for hospitalization; and 4.1 (95% CI 3.0-5.5) for death. Compared with SARS-CoV-2 Vaccine (Vero Cell), hazard ratios (HR) for contracting COVID-19 were 0.70 (95% CI 0.61-0.80) with AZD1222; 0.73 (95% CI 0.62-0.86) with Sputnik V; and 0.73 (95% CI 0.63-0.86) with CovIran®. For hospitalization and death, all vaccines provided similar protection 14 days after the second dose. History of COVID-19 protected against contracting COVID-19 again (HR 0.76; 95% CI 0.69-0.84). Diabetes and respiratory, cardiac and renal disease were associated with higher risks of contracting COVID-19 after vaccination.

Conclusion:

The rates of contracting COVID-19 after vaccination were relatively high. SARS-CoV-2 Vaccine (Vero Cell) provided lower protection against COVID-19 than other vaccines. People with comorbidities had higher risks of contracting COVID-19 and hospitalization and should be prioritized for preventive interventions.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines Limits: Humans Country/Region as subject: Asia Language: English Journal: Bull World Health Organ Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines Limits: Humans Country/Region as subject: Asia Language: English Journal: Bull World Health Organ Year: 2022 Document Type: Article