COVID-19 cases, hospitalizations and deaths after vaccination: a cohort event monitoring study, Islamic Republic of Iran.
Bull World Health Organ
; 100(8): 474-483, 2022 Aug 01.
Article
in English
| MEDLINE | ID: covidwho-1974569
ABSTRACT
Objective:
To investigate the incidence of coronavirus disease 2019 (COVID-19) cases, hospitalizations and deaths in Iranians vaccinated with either AZD1222 Vaxzevria, CovIran® vaccine, SARS-CoV-2 Vaccine (Vero Cell), Inactivated (lnCoV) or Sputnik V.Methods:
We enrolled individuals 18 years or older receiving their first COVID-19 vaccine dose between April 2021 and January 2022 in seven Iranian cities. Participants completed weekly follow-up surveys for 17 weeks (25 weeks for AZD1222) to report their COVID-19 status and hospitalization. We used Cox regression models to assess risk factors for contracting COVID-19, hospitalization and death.Findings:
Of 89 783 participants enrolled, incidence rates per 1 000 000 person-days were 528.2 (95% confidence interval, CI 514.0-542.7) for contracting COVID-19; 55.8 (95% CI 51.4-60.5) for hospitalization; and 4.1 (95% CI 3.0-5.5) for death. Compared with SARS-CoV-2 Vaccine (Vero Cell), hazard ratios (HR) for contracting COVID-19 were 0.70 (95% CI 0.61-0.80) with AZD1222; 0.73 (95% CI 0.62-0.86) with Sputnik V; and 0.73 (95% CI 0.63-0.86) with CovIran®. For hospitalization and death, all vaccines provided similar protection 14 days after the second dose. History of COVID-19 protected against contracting COVID-19 again (HR 0.76; 95% CI 0.69-0.84). Diabetes and respiratory, cardiac and renal disease were associated with higher risks of contracting COVID-19 after vaccination.Conclusion:
The rates of contracting COVID-19 after vaccination were relatively high. SARS-CoV-2 Vaccine (Vero Cell) provided lower protection against COVID-19 than other vaccines. People with comorbidities had higher risks of contracting COVID-19 and hospitalization and should be prioritized for preventive interventions.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Vaccines
/
COVID-19
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Topics:
Vaccines
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Bull World Health Organ
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS