Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Person.

Munnink, Bas B Oude; Nijhuis, Roel H T; Worp, Nathalie; Boter, Marjan; Weller, Babette; Verstrepen, Babs E; GeurtsvanKessel, Corine; Corsten, Maarten L; Russcher, Anne; Koopmans, Marion

Munnink, Bas B Oude; Nijhuis, Roel H T; Worp, Nathalie; Boter, Marjan; Weller, Babette; Verstrepen, Babs E; GeurtsvanKessel, Corine; Corsten, Maarten L; Russcher, Anne; Koopmans, Marion.

Emerg Infect Dis ; 28(9): 1920-1923, 2022 09.

Article in English | MEDLINE | ID: covidwho-1974606

ABSTRACT

ABSTRACT

We detected a highly divergent SARS-CoV-2 Alpha variant in an immunocompromised person several months after the latest detection of the Alpha variant in the Netherlands. The patient was infected for 42 weeks despite several treatment regimens and disappearance of most clinical symptoms. We identified several potential immune escape mutations in the spike protein.

Subject(s)

COVID-19; Mutation; SARS-CoV-2; COVID-19/immunology; Humans; Immunocompromised Host; Netherlands; SARS-CoV-2/classification; SARS-CoV-2/genetics; SARS-CoV-2/immunology; Spike Glycoprotein, Coronavirus/genetics

Keywords

Alpha variant; COVID-19; SARS-CoV-2; coronavirus disease; immunocompromised; respiratory infections; severe acute respiratory syndrome coronavirus 2; the Netherlands; variants; virus evolution; viruses; zoonoses

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Mutation Type of study: Case report / Prognostic study Topics: Variants Limits: Humans Country/Region as subject: Europa Language: English Journal: Emerg Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article

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