[Advances in clinical research of virus vector-based COVID-19 vaccines].
Zhonghua Yu Fang Yi Xue Za Zhi
; 56(8): 1127-1135, 2022 Aug 06.
Article
in Chinese
| MEDLINE | ID: covidwho-1974960
ABSTRACT
The COVID-19 outbreak at the end of 2019 has accelerated the development and research for COVID-19 vaccines worldwide. Among the COVID-19 vaccines in clinical trials developed via different platforms, recombinant virus vector-based vaccines have shown excellent immunogenicity and efficacy. However, at the same time, there are serious issues such as vaccine safety and pre-existing antibodies against vectors. This article summarizes the design concept and development history of recombinant virus vector-based vaccines, and focuses on the progress in the clinical studies of vector-based COVID-19 vaccines as well as the challenges, in order to provide reference for the research of recombinant vector-based vaccines.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Viral Vaccines
/
COVID-19
Type of study:
Prognostic study
Topics:
Vaccines
Limits:
Humans
Language:
Chinese
Journal:
Zhonghua Yu Fang Yi Xue Za Zhi
Year:
2022
Document Type:
Article
Affiliation country:
Cma.j.cn112150-20211101-01008
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