Pazopanib Is a Potential Treatment for Coronavirus-Induced Lung Injuries.
J Immunol
; 209(4): 723-730, 2022 08 15.
Article
in English
| MEDLINE | ID: covidwho-1975028
ABSTRACT
Severe acute respiratory syndrome coronavirus 2, responsible for the severe acute respiratory syndrome known as COVID-19, has rapidly spread in almost every country and devastated the global economy and health care system. Lung injury is an early disease manifestation believed to be a major contributor to short- and long-term pathological consequences of COVID-19, and thus drug discovery aiming to ameliorate lung injury could be a potential strategy to treat COVID-19 patients. By inducing a severe acute respiratory syndrome-like pulmonary disease model through infecting A/J mice with murine hepatitis virus strain 1 (MHV-1), we show that i.v. administration of pazopanib ameliorates acute lung injuries without affecting MHV-1 replication. Pazopanib reduces cell apoptosis in MHV-1-infected lungs. Furthermore, we also identified that pazopanib has to be given no later than 48 h after the virus infection without compromising the therapeutic effect. Our study provides a potential treatment for coronavirus-induced lung injuries and support for further evaluation of pazopanib in COVID-19 patients.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Murine hepatitis virus
/
Lung Injury
/
COVID-19 Drug Treatment
Type of study:
Experimental Studies
Limits:
Animals
Language:
English
Journal:
J Immunol
Year:
2022
Document Type:
Article
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