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COVID-19 and vaccination during pregnancy: a systematic analysis using Korea National Health Insurance claims data.
Ahn, Ki Hoon; Kim, Hae-In; Lee, Kwang-Sig; Heo, Ju Sun; Kim, Ho-Yeon; Cho, Geum-Joon; Hong, Soon-Cheol; Oh, Min-Jeong; Kim, Hae-Joong.
  • Ahn KH; Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.
  • Kim HI; Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.
  • Lee KS; School of Industrial Management Engineering, Korea University, Seoul, Korea.
  • Heo JS; AI Center, Korea University Anam Hospital, Seoul, Korea.
  • Kim HY; AI Center, Korea University Anam Hospital, Seoul, Korea.
  • Cho GJ; Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
  • Hong SC; Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.
  • Oh MJ; Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.
  • Kim HJ; Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.
Obstet Gynecol Sci ; 65(6): 487-501, 2022 Nov.
Article in English | MEDLINE | ID: covidwho-1975242
ABSTRACT

OBJECTIVE:

This study systematically analyzed coronavirus disease 2019 (COVID-19) and vaccination details during pregnancy by using the national health insurance claims data.

METHODS:

Population-based retrospective cohort data of 12,399,065 women aged 15-49 years were obtained from the Korea National Health Insurance Service claims database between 2019 and 2021. Univariate analysis was performed to compare the obstetric outcomes of pregnant women (ICD-10 O00-O94) and their newborns (ICD-10 P00-P96) with and without COVID-19. Univariate analysis was also performed to compare the age and obstetric outcomes of pregnant women receiving different types of vaccines.

RESULTS:

The percentage of pregnant women with COVID-19 during pregnancy was 0.11%. Some obstetric outcomes of pregnant women with COVID-19, including the rates of preterm birth or cesarean delivery, were significantly better than those of pregnant women without COVID-19. The rate of miscarriage was higher in pregnant women with COVID-19 than without COVID-19. However, the outcomes of newborns of women with and without COVID-19 were not significantly different. Regarding vaccination type, obstetric outcomes of pregnant women appeared to be worse with the viral vector vaccine than with the mRNA vaccine.

CONCLUSION:

To the best of our knowledge, this is the first study to systematically analyze COVID-19 and vaccination details during pregnancy using the national health insurance claims data in Korea. The obstetric outcomes in pregnant women with and without COVID-19 and their newborns were similar.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study / Systematic review/Meta Analysis Topics: Vaccines Language: English Journal: Obstet Gynecol Sci Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study / Systematic review/Meta Analysis Topics: Vaccines Language: English Journal: Obstet Gynecol Sci Year: 2022 Document Type: Article