Research progress of histone deacetylases inhibitors in antiviral drugs discovery
Acta Pharmaceutica Sinica
; 57(4):917-930, 2022.
Article
in Chinese
| GIM | ID: covidwho-1975501
ABSTRACT
Histone deacetylases (HDACs) are a class of key enzymes that regulate epigenetics. There are 5 small-molecule HDACs inhibitors having been approved for anti-cancer therapy on the market. In recent years, there have been more and more studies on the antiviral aspects of HDACs inhibitors. This article classifies viruses into human immunodeficiency virus 1 (HIV-1), new coronavirus (SARS-CoV-2), Epstein-Barr virus (EBV) and other viruses, systematically summarizes the recent advances of antiviral effects of the HDACs inhibitors from the perspective of medicinal chemistry. This review aims to provide the researchers the convenience of accessing the latest advances of the antiviral effects of HDACs inhibitors, and to analyze the challenges and prospects of this field in future drug discovery.
human diseases; antiviral agents; inhibitors; histones; drug development; enzymes; viral diseases; coronavirus disease 2019; HIV-1 infections; antiviral properties; drug therapy; man; viruses; Severe acute respiratory syndrome coronavirus 2; Human immunodeficiency virus 1; Human herpesvirus 4; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; Lentivirus; Orthoretrovirinae; Retroviridae; RNA Reverse Transcribing Viruses; Lymphocryptovirus; Gammaherpesvirinae; Herpesviridae; Herpesvirales; dsDNA Viruses; DNA Viruses; antivirals; SARS-CoV-2; viral infections; Epstein-Barr virus; anti-viral properties; chemotherapy
Full text:
Available
Collection:
Databases of international organizations
Database:
GIM
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2022
Document Type:
Article
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