Role of cardiac MRI in the diagnosis of immune checkpoint inhibitor-associated myocarditis.
Int J Cancer
; 151(11): 1860-1873, 2022 Dec 01.
Article
in English
| MEDLINE | ID: covidwho-1976728
ABSTRACT
Immune checkpoint inhibitor (ICI)-induced cardiotoxicity is a rare immune-related adverse event (irAE) characterized by a high mortality rate. From a pathological point of view, this condition can result from a series of causes, including binding of ICIs to target molecules on nonlymphocytic cells, cross-reaction of T lymphocytes against tumor antigens with off-target tissues, generation of autoantibodies and production of proinflammatory cytokines. The diagnosis of ICI-induced cardiotoxicity can be challenging, and cardiac magnetic resonance (CMR) represents the diagnostic tool of choice in clinically stable patients with suspected myocarditis. CMR is gaining a central role in diagnosis and monitoring of cardiovascular damage in cancer patients, and it is entering international cardiology and oncology guidelines. In this narrative review, we summarized the clinical aspects of ICI-associated myocarditis, highlighting its radiological aspects and proposing a novel algorithm for the use of CMR.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Myocarditis
Type of study:
Prognostic study
/
Randomized controlled trials
/
Reviews
Limits:
Humans
Language:
English
Journal:
Int J Cancer
Year:
2022
Document Type:
Article
Affiliation country:
Ijc.34169
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