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Clinical utility of circulating calprotectin to assist prediction and monitoring of COVID-19 severity: An Italian study.
Infantino, Maria; Manfredi, Mariangela; Alessio, Maria Grazia; Previtali, Giulia; Grossi, Valentina; Benucci, Maurizio; Faraone, Antonio; Fortini, Alberto; Grifoni, Elisa; Masotti, Luca; Russo, Edda; Amedei, Amedeo; FitzGerald, Emily; Albesa, Roger; Norman, Gary L; Mahler, Michael.
  • Infantino M; Immunology and Allergology Laboratory Unit, San Giovanni di Dio Hospital, Florence, Italy.
  • Manfredi M; Immunology and Allergology Laboratory Unit, San Giovanni di Dio Hospital, Florence, Italy.
  • Alessio MG; Department of Laboratory Medicine, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.
  • Previtali G; Department of Laboratory Medicine, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.
  • Grossi V; Immunology and Allergology Laboratory Unit, San Giovanni di Dio Hospital, Florence, Italy.
  • Benucci M; Rheumatology Unit, San Giovanni di Dio Hospital, Florence, Italy.
  • Faraone A; Department of Internal Medicine, San Giovanni Di Dio Hospital, Florence, Italy.
  • Fortini A; Department of Internal Medicine, San Giovanni Di Dio Hospital, Florence, Italy.
  • Grifoni E; Internal Medicine II, San Giuseppe Hospital, Empoli, Italy.
  • Masotti L; Internal Medicine II, San Giuseppe Hospital, Empoli, Italy.
  • Russo E; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Amedei A; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • FitzGerald E; Headquarters & Technology Center Autoimmunity, Werfen, San Diego, California, USA.
  • Albesa R; Headquarters & Technology Center Autoimmunity, Werfen, San Diego, California, USA.
  • Norman GL; Headquarters & Technology Center Autoimmunity, Werfen, San Diego, California, USA.
  • Mahler M; Headquarters & Technology Center Autoimmunity, Werfen, San Diego, California, USA.
J Med Virol ; 94(12): 5758-5765, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-1976743
ABSTRACT

BACKGROUND:

Calprotectin (S100A8/A9) has been identified as a biomarker that can aid in predicting the severity of disease in COVID-19 patients. This study aims to evaluate the correlation between levels of circulating calprotectin (cCP) and the severity of COVID-19.

METHODS:

Sera from 245 COVID-19 patients and 110 apparently healthy individuals were tested for calprotectin levels using a chemiluminescent immunoassay (Inova Diagnostics). Intensive care unit (ICU) admission and type of respiratory support administered were used as indicators of disease severity, and their correlation with calprotectin levels was assessed.

RESULTS:

Samples from patients in the ICU had a median calprotectin concentration of 11.6 µg/ml as compared to 3.5 µg/ml from COVID-19 patients who were not in the ICU. The median calprotectin concentration in a cohort of healthy individuals collected before the COVID-19 pandemic was 3.0 µg/ml (95% CI 2.820-2.969 µg/ml). Patients requiring a Venturi mask, continuous positive airway pressure, or orotracheal intubation all had significantly higher values of calprotectin than controls, with the increase of cCP levels proportional to the increasing need of respiratory support.

CONCLUSION:

Calprotectin levels in serum correlate well with disease severity and represent a promising serological biomarker for the risk assessment of COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Leukocyte L1 Antigen Complex / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.28056

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Leukocyte L1 Antigen Complex / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.28056