Clinical outcomes of COVID-19 infection in patients with pre-existing cardiovascular disease.
Am Heart J Plus
; 20: 100189, 2022 Aug.
Article
in English
| MEDLINE | ID: covidwho-1976924
ABSTRACT
Introduction:
Patients with pre-existing cardiovascular disease may carry a higher risk for mortality from COVID-19. This study examined the association between individuals with pre-existing cardiovascular disease admitted for COVID-19 and their clinical outcomes.Methods:
A retrospective cohort study was conducted on patients admitted with COVID-19 to Rush University System for Health (RUSH) to identify cardiovascular risk factors associated with increased mortality and major adverse cardiovascular events (MACE; a composite of cardiovascular death, stroke, myocardial injury, and heart failure exacerbation). Multivariable logistic regression was used to adjust for demographic data and comorbid conditions.Results:
Of the 1682 patients who met inclusion criteria, the median age was 59. Patients were predominantly African American (34.4 %) and male (54.5 %). Overall, 202 (12 %) patients suffered 60-day mortality. In the multivariable model that assessed risk factors for 60-day mortality, age 60-74 (adjusted odds ratio [aOR] 3.30 [CI 1.23-10.62]; p < 0.05) and age 75-100 (aOR 4.52 [CI 1.46-16.15]; p < 0.05) were significant predictors when compared to those aged 19 to 39. This model also showed that those with past medical histories of atrial fibrillation (aOR 2.47 [CI 1.38-4.38]; p < 0.01) and venous thromboembolism (aOR 2.00 [CI 1.12-3.50]; p < 0.05) were at higher risk of 60-day mortality.Conclusion:
In this cohort, patients over 60 years old with a pre-existing history of atrial fibrillation and venous thromboembolism were at increased risk of mortality from COVID-19.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Language:
English
Journal:
Am Heart J Plus
Year:
2022
Document Type:
Article
Affiliation country:
J.AHJO.2022.100189
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