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COVID-19 vaccine-related Guillain-Barré syndrome in the Liguria region of Italy: A multicenter case series.
Germano, Francesco; Bellucci, Margherita; Grisanti, Stefano; Beronio, Alessandro; Grazzini, Matteo; Coco, Elena; Tassinari, Tiziana; Della Cava, Fabio; De Michelis, Chiara; Baldi, Ottavia; Sivori, Giorgia; Murialdo, Alessandra; Cabona, Corrado; Durando, Paolo; Uccelli, Antonio; Schenone, Angelo; Franciotta, Diego; Benedetti, Luana.
  • Germano F; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy.
  • Bellucci M; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy.
  • Grisanti S; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy.
  • Beronio A; Department of Neurology, Sant'Andrea Hospital, La Spezia, Italy.
  • Grazzini M; Department of Neurology, Sant'Andrea Hospital, La Spezia, Italy.
  • Coco E; Department of Neurology Santa Corona Hospital, Pietra Ligure, Savona, Italy.
  • Tassinari T; Department of Neurology Santa Corona Hospital, Pietra Ligure, Savona, Italy.
  • Della Cava F; Department of Neurology, Imperia Hospital, Imperia, Italy.
  • De Michelis C; Department of Neurology, Imperia Hospital, Imperia, Italy.
  • Baldi O; Department of Neurology, S. Paolo Hospital, Savona, Italy.
  • Sivori G; Department of Neurology, Lavagna, Italy.
  • Murialdo A; IRCCS, Ospedale Policlinico San Martino, Genova, Italy.
  • Cabona C; IRCCS, Ospedale Policlinico San Martino, Genova, Italy.
  • Durando P; IRCCS, Ospedale Policlinico San Martino, Genova, Italy.
  • Uccelli A; IRCCS, Ospedale Policlinico San Martino, Genova, Italy.
  • Schenone A; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy; IRCCS, Ospedale Policlinico San Martino, Genova, Italy.
  • Franciotta D; IRCCS, Ospedale Policlinico San Martino, Genova, Italy.
  • Benedetti L; IRCCS, Ospedale Policlinico San Martino, Genova, Italy. Electronic address: luana.benedetti@hsanmartino.it.
J Neurol Sci ; 440: 120330, 2022 09 15.
Article in English | MEDLINE | ID: covidwho-1977545
ABSTRACT
BACKGROUND AND

PURPOSE:

Guillain-Barré-Syndrome (GBS) can follow COVID-19 vaccination, with clinical and paraclinical features still to be precisely assessed. We describe a cohort of patients who developed GBS after vaccination with different types of COVID-19 vaccines.

METHODS:

Patients with post-COVID-19 vaccination GBS, admitted to the six hospitals that cover the whole Liguria Region, Northwestern Italy, from February 1st to October 30th 2021, were included. Clinical, demographic, and paraclinical data were retrospectively collected.

RESULTS:

Among the 13 patients with post-COVID-19 vaccination GBS (9 males; mean age, 64 year), 5 were vaccinated with Oxford-AstraZeneca, 7 with Pfizer-BioNTech, and one with Moderna. Mean time between vaccination and GBS onset was 11.5 days. Ten patients developed GBS after the first vaccination dose, 3 after the second dose. Acute inflammatory demyelinating polyradiculoneuropathy (AIDP) was the predominant GBS variant, mainly characterized by sensory involvement. Bilateral seventh cranial nerve involvement followed AstraZeneca vaccination in two cases. Three patients presented treatment-related fluctuations, and 4 mild symptoms that delayed treatments and negatively affected prognosis. Prognosis was poor (GBS-disability score, ≥3) in 5/13 patients, with a disability rate of 3/13.

CONCLUSIONS:

Our findings confirm that most post-COVID-19 vaccination GBS belong to the AIDP subtype, and occur after the first vaccine dose. Treatment-related fluctuations, and diagnosis-delaying, mild symptoms at onset are clinical features that affect prognosis and deserve particular consideration.
Subject(s)
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Guillain-Barre Syndrome / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Long Covid / Vaccines / Variants Limits: Humans / Male / Middle aged Language: English Journal: J Neurol Sci Year: 2022 Document Type: Article Affiliation country: J.jns.2022.120330

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Guillain-Barre Syndrome / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Long Covid / Vaccines / Variants Limits: Humans / Male / Middle aged Language: English Journal: J Neurol Sci Year: 2022 Document Type: Article Affiliation country: J.jns.2022.120330