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Inhibition of SARS-CoV-2 Infection by the Cyclophilin Inhibitor Alisporivir (Debio 025).
Softic, Laurent; Brillet, Rozenn; Berry, François; Ahnou, Nazim; Nevers, Quentin; Morin-Dewaele, Margot; Hamadat, Sabah; Bruscella, Patrice; Fourati, Slim; Pawlotsky, Jean-Michel; Ahmed-Belkacem, Abdelhakim.
  • Softic L; Research Team "Viruses, Hepatology, Cancer," Institut Mondor de Recherche Biomédicale, INSERM U955, Créteil, France.
  • Brillet R; Research Team "Viruses, Hepatology, Cancer," Institut Mondor de Recherche Biomédicale, INSERM U955, Créteil, France.
  • Berry F; Research Team "Viruses, Hepatology, Cancer," Institut Mondor de Recherche Biomédicale, INSERM U955, Créteil, France.
  • Ahnou N; Research Team "Viruses, Hepatology, Cancer," Institut Mondor de Recherche Biomédicale, INSERM U955, Créteil, France.
  • Nevers Q; Research Team "Viruses, Hepatology, Cancer," Institut Mondor de Recherche Biomédicale, INSERM U955, Créteil, France.
  • Morin-Dewaele M; Research Team "Viruses, Hepatology, Cancer," Institut Mondor de Recherche Biomédicale, INSERM U955, Créteil, France.
  • Hamadat S; Research Team "Viruses, Hepatology, Cancer," Institut Mondor de Recherche Biomédicale, INSERM U955, Créteil, France.
  • Bruscella P; Research Team "Viruses, Hepatology, Cancer," Institut Mondor de Recherche Biomédicale, INSERM U955, Créteil, France.
  • Fourati S; Research Team "Viruses, Hepatology, Cancer," Institut Mondor de Recherche Biomédicale, INSERM U955, Créteil, France.
  • Pawlotsky JM; Department of Virology, Hôpital Henri Mondor, Université Paris-Est, Créteil, France.
  • Ahmed-Belkacem A; Research Team "Viruses, Hepatology, Cancer," Institut Mondor de Recherche Biomédicale, INSERM U955, Créteil, France jean-michel.pawlotsky@aphp.fr.
Antimicrob Agents Chemother ; 64(7)2020 06 23.
Article in English | MEDLINE | ID: covidwho-197789
ABSTRACT
Cyclophilins play a key role in the life cycle of coronaviruses. Alisporivir (Debio 025) is a nonimmunosuppressive analogue of cyclosporine with potent cyclophilin inhibition properties. Alisporivir reduced SARS-CoV-2 RNA production in a dose-dependent manner in Vero E6 cells, with a 50% effective concentration (EC50) of 0.46 ± 0.04 µM. Alisporivir inhibited a postentry step of the SARS-CoV-2 life cycle. These results justify rapidly conducting a proof-of-concept phase 2 trial with alisporivir in patients with SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Cyclosporine / Coronavirus Infections / Cyclophilins / Betacoronavirus Type of study: Randomized controlled trials Limits: Animals / Humans Language: English Year: 2020 Document Type: Article Affiliation country: AAC.00876-20

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Cyclosporine / Coronavirus Infections / Cyclophilins / Betacoronavirus Type of study: Randomized controlled trials Limits: Animals / Humans Language: English Year: 2020 Document Type: Article Affiliation country: AAC.00876-20