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Placental Injury and Antibody Transfer Following COVID-19 Disease in Pregnancy.
Timi, Patience; Kellerhals, Sarah E; Joseph, Naima T; Dude, Carolynn M; Verkerke, Hans P; Irby, Les'Shon S; Smith, Alicia K; Stowell, Sean R; Jamieson, Denise J; Badell, Martina L.
  • Timi P; Emory University School of Medicine, Atlanta, GA, USA.
  • Kellerhals SE; Department of Obstetrics and Gynecology, University of Arizona College of Medicine, Phoenix, AZ, USA.
  • Joseph NT; Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.
  • Dude CM; Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Verkerke HP; Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.
  • Irby LS; Department of Pathology and Laboratory medicine, Emory University School of Medicine, Atlanta, GA, USA.
  • Smith AK; Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.
  • Stowell SR; Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.
  • Jamieson DJ; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Badell ML; Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.
J Infect Dis ; 2022 Jun 29.
Article in English | MEDLINE | ID: covidwho-2304792
ABSTRACT
We examined the relationship between placental histopathology and transplacental antibody transfer in pregnant patients following SARS-CoV-2 infection. Differences in plasma concentrations of anti-Receptor Biding Domain (RBD) Immunoglobulin (Ig) G antibodies in maternal and cord blood were analyzed according to presence of placental injury. Median [IQR] anti-RBD IgG concentrations in cord blood with placental injury (n = 7) did not differ significantly from those without injury (n= 16) [(2.7 [1.8,3.6] vs 2.7[2.4, 2.9], p= 0.59). However, they were associated with lower transfer ratios (median [IQR] 0.77[0.61, 0.97] vs. 0.97[0.80, 1.01], p = 0.05) suggesting that SARS-CoV-2 placental injury mediates reduced maternal-fetal antibody transfer.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Year: 2022 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Language: English Year: 2022 Document Type: Article Affiliation country: Infdis