Parkinson's disease induced by SARSCoV2
European Journal of Neurology
; 29:777, 2022.
Article
in English
| EMBASE | ID: covidwho-1978464
ABSTRACT
Background and aims:
COVID-19 infections are reported in numerous case-reports as a trigger for development of Parkinson's disease (PD). We report 4 patients with symptoms of PD developed or exagerated after SARSCoV2 infection.Methods:
Patients were retrospectively recruited in an outpatient clinic of Department of Neurology, Faculty of Health Science, Medical University of Warsaw. Patients were independently assessed by 2 neurologists experienced in movement disorders.Results:
We identified 4 patients with rapid onset of PD symptoms following COVID-19. All patients were female. Symptoms of COVID-19 included headache in 4/4 cases and anosmia in 3/4 cases. PCR test confirmed SARS-CoV2 infection in all cases. The age of onset was between 28 and 62 years old. The rest tremor was present in all patients, ridgidity in 3/4 patients. Non-motor symptoms included RBD in 2/4 patients. Two patients were treated with levodopa with good response. MRI findings were nonsignificant. The SPECT-DatScan was performed in one patient and was typical for parkinsonian disorders. The positive family history was present in two patients.Conclusion:
We conclude that COVID-19 may trigger development of parkinsonian motor symptoms or exaggerate the slight disease progression. The cause is unknown. Involvement of olfactory bulb could trigger neuroinflammation in line with Braak's hypothesis. COVID-19 may also induce parkinsonism in patients with genetic predisposition.
ioflupane i 123; levodopa; adult; anosmia; conference abstract; coronavirus disease 2019; drug therapy; family history; female; headache; human; human cell; in vitro study; motor dysfunction; nervous system inflammation; neurologist; neurology; nuclear magnetic resonance imaging; olfactory bulb; onset age; outpatient department; Parkinson disease; parkinsonism; retrospective study; single photon emission computed tomography; tremor
Full text:
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Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
European Journal of Neurology
Year:
2022
Document Type:
Article
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